2-Hydroxy-naphthaldehyde

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Names

[ CAS No. ]:
708-06-5

[ Name ]:
2-Hydroxy-naphthaldehyde

[Synonym ]:
2-Hydroxy-1-naphthaldehyde
2-hydroxynaphthalene-1-carboxaldehyde
1-naphthalenecarboxaldehyde, 2-hydroxy
1-Naphthalenecarboxaldehyde, 2-hydroxy-
EINECS 211-902-0
2-Hydroxy-naphthaldehyde
MFCD00004005
.β.-Hydroxy-.α.-naphthaldehyde

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
305.8±0.0 °C at 760 mmHg

[ Melting Point ]:
82-85ºC

[ Molecular Formula ]:
C11H8O2

[ Molecular Weight ]:
172.18

[ Flash Point ]:
134.3±13.0 °C

[ Exact Mass ]:
172.052429

[ PSA ]:
37.30000

[ LogP ]:
2.84

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.719

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ0300000
CHEMICAL NAME :
1-Naphthaldehyde, 2-hydroxy-
CAS REGISTRY NUMBER :
708-06-5
BEILSTEIN REFERENCE NO. :
0742777
LAST UPDATED :
199709
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C11-H8-O2
MOLECULAR WEIGHT :
172.19
WISWESSER LINE NOTATION :
T66J BVH CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
710 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),85,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1170 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),85,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7250 mg/kg/5D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),86,1986
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 gm/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume decreased Blood - change in clotting factors Blood - changes in leukocyte (WBC) count
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),86,1986

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H400

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;N: Dangerous for the environment;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
UN 3077 9

[ WGK Germany ]:
2

[ RTECS ]:
QJ0300000

[ HS Code ]:
2912499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Chloroform
  • 2-Naphthol
  • 1-Naphthalenecarboxaldehyde,2-methoxy-
  • N,N-Dimethylformamide
  • 6-(2-hydroxy-naphthalen-1-yl)-1,3,5-trimethyl-[1,3,5]triazinane-2,4-dione
  • naphthalen-2-yl formate
  • 1-(trimethylsilyl)-2-naphthyl triflate
  • Aminoform
  • Formic Acid
  • 1-Naphthalenecarboxaldehyde,2-hydroxy-, oxime

DownStream

  • 2-BUTOXY-1-NAPHTHALDEHYDE
  • 3-(2-methoxynaphthalen-1-yl)prop-2-enoic acid
  • 2-(3-phenylprop-2-enoxy)naphthalene-1-carbaldehyde
  • 2-[(2-oxonaphthalen-1-ylidene)methylamino]benzamide
  • acetic acid,[1-(dihydroxymethyl)naphthalen-2-yl] acetate
  • Salermide
  • Sirtinol
  • Phthalide-3-Acetic Acid
  • 2-[(E)-2-Carboxyvinyl]benzoic acid
  • 1-Nitro-2-naphthol

Customs

[ HS Code ]: 2912499000

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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Related Compounds

  • 2-HYDROXY-NAPHTHALDEHYDE
  • 2-hydroxy-naphthaldehyde-(1-){2-hydroxy-ethylimine}
  • 2-HYDROXY-1-NAPHTHALDEHYDE ISONICOTINOYL HYDRAZONE
  • 2-Hydroxy-1-naphthaldehyde sodium salt
  • 2-Hydroxy-7-methoxy-1-naphthaldehyde
  • 2-hydroxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthaldehyde