Terodiline hydrochloride

Suppliers

Names

[ Name ]:
Terodiline hydrochloride

[Synonym ]:
Propylamine,N-tert-butyl-1-methyl-3,3-diphenyl-,hydrochloride
N-tert-Butyl-1-methyl-3,3-diphenylpropylamine hydrochloride
TERODILINE HYDROCHLORIDE
Bicor
N-t-Butyl-1-methyl-3,3-diphenylpropylamine hydrochloride
Terodiline chloride
TD-758
Terodiline HCl

Chemical & Physical Properties

[ Boiling Point ]:
390.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₈ClN

[ Molecular Weight ]:
317.89600

[ Flash Point ]:
168.9ºC

[ Exact Mass ]:
317.19100

[ PSA ]:
12.03000

[ LogP ]:
6.17810

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319-H400

[ Precautionary Statements ]:
P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
22-36-50

[ RIDADR ]:
UN 3077 9/PG 3

[ RTECS ]:
UH9970000

Articles

Action potentials, contraction, and membrane currents in guinea pig ventricular preparations treated with the antispasmodic agent terodiline.

J. Pharmacol. Exp. Ther. 290(3) , 1417-26, (1999)

Terodiline was widely prescribed for urinary incontinence before reports of adverse cardiac effects that included bradycardia, QT lengthening, and ventricular tachyarrhythmia. The present study on gui...

Comparison of the effects of NS-21 and terodiline on the QTc interval in dogs.

Gen. Pharmacol. 30(1) , 137-42, (1998)

1. NS-21 [(+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate], its active metabolite, RCC-36, and terodiline, are mixed anticholinergic...

CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.

Br. J. Clin. Pharmacol. 50(1) , 77-80, (2000)

Terodiline has concentration dependent QT prolonging effects and thus the potential for cardiotoxicity. Pharmacogenetic variation in terodiline metabolism could be responsible for cardiotoxicity. We s...