Nafimidone

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Names

[ CAS No. ]:
70891-37-1

[ Name ]:
Nafimidone

[Synonym ]:
2-imidazol-1-yl-1-naphthalen-2-yl-ethanone hydrochloride
2-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone monohydrochloride
Nafimidone hydrochloride (USAN)
Ethanone,2-(1H-imidazol-1-yl)-1-(2-naphthalenyl)-,monohydrochloride
2-(1-Imidazolylacetyl)naphthalene hydrochloride
2'-ACETONAPHTHONE,2-(1-IMIDAZOLYL)-,HYDROCHLORIDE
Nafimidone HCl
1-(2-Naphthoylmethyl)imidazole hydrochloride
2-(1H-imidazol-1-yl)-1-(naphthalen-2-yl)ethanone hydrochloride
Nafimidone hydrochloride

Chemical & Physical Properties

[ Molecular Formula ]:
C15H13ClN2O

[ Molecular Weight ]:
272.73000

[ Exact Mass ]:
272.07200

[ PSA ]:
34.89000

[ LogP ]:
3.72120

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM5780880
CHEMICAL NAME :
Ethanone, 2-(1H-imidazol-1-yl)-1-(2-naphthalenyl)-, monohydrochloride
CAS REGISTRY NUMBER :
70891-37-1
LAST UPDATED :
199203
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C15-H12-N2-O.Cl-H
MOLECULAR WEIGHT :
272.75
WISWESSER LINE NOTATION :
L66J BV1- AT5N CNJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
504 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,1577,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 120,185,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
210 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 120,185,1981

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Imidazole
  • 2-Bromo-1-(2-naphthyl)ethanone

DownStream

  • 1-[(2-naphthalen-2-yl-1,3-dioxolan-2-yl)methyl]imidazole,hydrochloride
  • 1-[2,2-bis(ethylsulfanyl)-2-naphthalen-2-ylethyl]imidazole
  • nafimidone alcohol

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • NAFIMIDONE
  • nafimidone oxime
  • nafimidone alcohol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]-6-oxopyridazin-1(6H)-yl}-N-[(2Z)-4,5-dimethyl-1,3-thiazol-2(3H)-ylidene]acetamide
  • 1-(2-{[(Tert-butoxycarbonyl)amino]-methyl}phenyl)-1h-imidazole-4-carboxylic acid
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 8-Pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
  • 1-(3-Chloropyridin-2-yl)-4-isopropylpiperazine
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide