cytosine

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Names

[ CAS No. ]:
71-30-7

[ Name ]:
cytosine

[Synonym ]:
MFCD00006034
Cytosin
EINECS 200-749-5
Cytosinimine
Cytosine
4-aminopyrimidin-2-one
Cyt
Lamivudine Impurity 5
6-Aminopyrimidin-2(1H)-one

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
445.8ºC at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C4H5N3O

[ Molecular Weight ]:
111.102

[ Flash Point ]:
223.4ºC

[ Exact Mass ]:
111.043259

[ PSA ]:
71.77000

[ LogP ]:
-2.29

[ Index of Refraction ]:
1.689

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UW7350150
CHEMICAL NAME :
2(1H)-Pyrimidinone, 4-amino-
CAS REGISTRY NUMBER :
71-30-7
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C4-H5-N3-O
MOLECULAR WEIGHT :
111.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2222 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 207,504,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3859 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 312 (estimated) No. of Female Employees: 303 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
UW7350150

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2(1H)-Pyrimidinone,6-[(phenylmethyl)amino]-
  • 3,3-Diethoxypropanenitrile
  • 3-ethoxyacrylonitrile
  • N4-[(Dimethylamino)methylene]cytosine
  • 2(1H)-Pyrimidinone, 4-ethoxy- (6CI,7CI,8CI,9CI)
  • 2'-Deoxycytidine monohydrate
  • Benzoic anhydride
  • 2-Methoxypyrimidin-4-amine

DownStream

  • Dichloroacetonitrile
  • Cyanogen chloride
  • Trimethylsilanyl-(2-trimethylsilanyloxy-pyrimidin-4-yl)-amine
  • Dihydrouracil
  • 5-Bromouracil
  • 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
  • 2(1H)-Pyrimidinone,4-amino-1-methyl-
  • 1-methyl-4-(methylamino)pyrimidin-2-one
  • 4-(dimethylamino)-1-methylpyrimidin-2-one

Customs

[ HS Code ]: 2933591000

[ Summary ]:
HS:2933591000 4-aminopyrimidin-2(1h)-one VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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Related Compounds

  • AZACYTOSINE
  • Isocytosine
  • Cytosine API
  • Cytosine-5-t
  • Ag(cytosine)
  • ara-Cytosine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • tert-butyl N-[2-amino-3-(4-hydroxy-3-methoxyphenyl)propyl]carbamate
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 3-(3-Bromophenyl)-5-chloro-2-fluoropyridine
  • (1-(Aminomethyl)-2,2-difluorocyclopropyl)methanol
  • 5-(1-Methoxycyclopropyl)-1,3,4-thiadiazol-2-amine
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide