Spermine
Suppliers
Names
[ CAS No. ]:
71-44-3
[ Name ]:
Spermine
[Synonym ]:
Spermin
1,4-Butanediamine, N,N-bis(3-aminopropyl)-
MUSCULAMINE HYDROCHLORIDE
EINECS 200-754-2
N,N'-Bis(3-aminopropyl)butane-1,4-diamine
N,N'-Bis(3-aminopropyl)-1,4-butanediamine
N,N'-Bis(3-aminopropyl)butan-1,4-diamin
N,N'-Bis(3-aminopropyl)-1,4-diaminobutane
N,N'-Bis(3-aminopropyl)tetramethylenediamine
Spermine
SPERMINE HYDROCHLORIDE
MFCD00012914
1,5,10,14-Tetraazatetradecane
NEURIDINE HYDROCHLORIDE
N1,N4-bis(3-aminopropyl)-1,4-butanediamine
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
308.4±0.0 °C at 760 mmHg
[ Melting Point ]:
310-311 °C (dec.)(lit.)
[ Molecular Formula ]:
C10H26N4
[ Molecular Weight ]:
202.340
[ Flash Point ]:
175.6±22.6 °C
[ Exact Mass ]:
202.215744
[ PSA ]:
76.10000
[ LogP ]:
-0.96
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.485
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
H2O: 1 M at 20 °C, clear, colorless
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EJ7175000
- CHEMICAL NAME :
- 1,4-Butanediamine, N,N'-bis(3-aminopropyl)-
- CAS REGISTRY NUMBER :
- 71-44-3
- BEILSTEIN REFERENCE NO. :
- 1750791
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C10-H26-N4
- MOLECULAR WEIGHT :
- 202.40
- WISWESSER LINE NOTATION :
- Z3M4M3Z
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - dehydration
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD30 - Lethal Dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 650 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD30 - Lethal Dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - hamster Kidney
- DOSE/DURATION :
- 2 mmol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 40,1893,1990
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
C: Corrosive;Xi: Irritant;
[ Risk Phrases ]:
R34
[ Safety Phrases ]:
S26-S36-S45-S36/37/39
[ RIDADR ]:
UN 3259 8/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
EJ7230000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
2929909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921290000
[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
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