1,3-Diazaspiro(4.7)dodecane-2,4-dione

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Names

[ CAS No. ]:
710-94-1

[ Name ]:
1,3-Diazaspiro(4.7)dodecane-2,4-dione

[Synonym ]:
cyclooctanespiro-5-hydantoin
5,5-Cycloheptamethylene hydantoin

Chemical & Physical Properties

[ Density]:
1.17g/cm3

[ Molecular Formula ]:
C10H16N2O2

[ Molecular Weight ]:
196.24600

[ Exact Mass ]:
196.12100

[ PSA ]:
58.20000

[ LogP ]:
1.96650

[ Index of Refraction ]:
1.534

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HM2945900
CHEMICAL NAME :
1,3-Diazaspiro(4.7)dodecane-2,4-dione
CAS REGISTRY NUMBER :
710-94-1
BEILSTEIN REFERENCE NO. :
0161789
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H16-N2-O2
MOLECULAR WEIGHT :
196.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,239,1965

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Cyclooctanone
  • POTASSIUM CYANIDE
  • Ammonium carbonate
  • sodium cyanide
  • Sodium cyanide

DownStream

  • BOC-1-AMINO-1-CYCLOOCTANECARBOXYLIC ACID
  • 1-Aminocyclooctanecarboxylic acid
  • Methyl 1-aminocyclooctanecarboxylate hydrochloride

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 3-methyl-1,3-diazaspiro[4.7]dodecane-2,4-dione
  • 1,3-Diazaspiro[4.4]nonane-2,4-dione,1-acetyl-
  • 1,3-Diazaspiro[4.4]nonane-2,4-dione
  • 1,3-diazaspiro[4.5]decane-2,4-dione
  • 1,3-Diazaspiro[4.4]nonane-2,4-dione,6-phenyl-
  • 1,3-Diazaspiro[4.6]undecane-2,4-dione,3-(4-morpholinylmethyl)-