Melevodopa

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Names

[ CAS No. ]:
7101-51-1

[ Name ]:
Melevodopa

[Synonym ]:
3-Hydroxy-L-tyrosine methyl ester
(S)-(-)-methyl 2-amino-3-(3,4-dihydroxyphenyl)propanoate
(S)-2-Amino-3-(3,4-dihydroxy-phenyl
3,4-dihydroxy-L-phenylalanine methyl ester
L-Dopa methyl ester
Levodopa methyl ester
Melevodopa (INN)
methyl-L-DOPA
Melevodopa
(2S)-2-amino-3-(3,4-dihydroxy-phenyl)-propionic acid methyl ester

Chemical & Physical Properties

[ Density]:
1.322g/cm3

[ Boiling Point ]:
384.4ºC at 760 mmHg

[ Molecular Formula ]:
C10H13NO4

[ Molecular Weight ]:
211.21500

[ Flash Point ]:
186.3ºC

[ Exact Mass ]:
211.08400

[ PSA ]:
92.78000

[ LogP ]:
0.84090

[ Index of Refraction ]:
1.592

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY5960000
CHEMICAL NAME :
Alanine, 3-(3,4-dihydroxyphenyl)-, methyl ester, L-
CAS REGISTRY NUMBER :
7101-51-1
BEILSTEIN REFERENCE NO. :
3056415
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H13-N-O4
MOLECULAR WEIGHT :
211.24
WISWESSER LINE NOTATION :
QR BQ D1YZVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
DOSE/DURATION :
3300 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,1414,1980

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methanol
  • Levodopa
  • 3-Hydroxy-N-[(phenylmethoxy)carbonyl]-O-(phenylmethyl)-L-tyrosine Methyl Ester
  • L-Tyrosine
  • 3-Acetyl-N-benzyloxycarbonyl-L-tyrosine Methyl Ester
  • (2S)-2-AMINO-3-HYDROXY-PROPANOICACID
  • (S)-2-PHENYLPYRROLIDINE
  • 3-Acetyl-N-benzyloxycarbonyl-4-O-benzyl-L-tyrosine Methyl Ester
  • H-Tyr-OMe
  • Melevodopa

DownStream

  • Levodopa
  • Melevodopa
  • (+/-)-3-(3,4-dihydroxyphenyl)-2-methyl-DL-alanine
  • D-dopa
  • methyl 5,6-dihydroxy-1H-indole-2-carboxylate

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 2-[4-(9-ethyl-9H-purin-6-yl)piperazin-1-yl]-1-(4-phenylpiperazin-1-yl)ethan-1-one
  • 4-Ethyl-1-(3-methyl-1,2-thiazol-5-yl)cyclohex-2-en-1-ol
  • N-(3-methylphenyl)-2-[4-(1,3-thiazol-2-yloxy)piperidin-1-yl]acetamide
  • 2-[4-(cyclopropanesulfonyl)-1,4-diazepan-1-yl]-N-(prop-2-en-1-yl)acetamide
  • 5-Acetyl-3-iodo-2-methylbenzonitrile
  • N-methyl-1,1-dioxo-N-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-1,2-benzothiazol-3-amine
  • Tert-butyl (3-(4-amino-2-(trifluoromethyl)phenoxy)propyl)carbamate
  • 2-Bromo-6-fluoro-3-(trifluoromethoxy)benzonitrile
  • Methyl 2-bromo-6-methoxy-3-nitrobenzoate
  • Benzyl 4-[2-(Boc-amino)acetamido]butanoate
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