Leukotriene B4

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Names

[ CAS No. ]:
71160-24-2

[ Name ]:
Leukotriene B4

[Synonym ]:
(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenoic acid
Leukotriene B4
6Z,8E,10E,14Z,5S,12R-diHETE
(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid
EINECS 200-578-6
LTB4
Leukotriene B4,(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoicacid
Leukotriene B4 Lipid Maps MS Standard
MFCD00135630
6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)-

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
536.4±50.0 °C at 760 mmHg

[ Melting Point ]:
-144.0 °C (lit.)

[ Molecular Formula ]:
C20H32O4

[ Molecular Weight ]:
336.466

[ Flash Point ]:
292.3±26.6 °C

[ Exact Mass ]:
336.230072

[ PSA ]:
77.76000

[ LogP ]:
4.06

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.527

[ Storage condition ]:
−20°C

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ Hazard Codes ]:
F: Flammable;

[ Risk Phrases ]:
11

[ Safety Phrases ]:
S7-S16

[ RIDADR ]:
UN 1170 3/PG 2

[ WGK Germany ]:
1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • LEUKOTRIENE B4, METHYL ESTER
  • Methyl 5-chloro-5-oxopentanoate
  • 6-Heptynoic acid, 5-hydroxy-, methyl ester, (5S)
  • 5(S),12(R)-bis[(tert-butyldimethylsilyl)oxy]-6(7),8(E),10(E),14(Z)-eicosatetraenoic acid
  • 4-Decynal, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (R)
  • 4-Decyn-1-ol, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (R)
  • methyl 5-oxo-7-trimethylsilylhept-6-ynoate

DownStream

Articles

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production.

Antimicrob. Agents Chemother. 58(8) , 4298-307, (2014)

The accumulation of neutrophils and proinflammatory mediators, such as leukotriene B4 (LTB4), is a classic marker of inflammatory disease. The clearance of apoptotic neutrophils, inhibition of proinfl...


More Articles

Related Compounds

  • Leukotriene B4
  • Leukotriene B4-d4
  • 8,15-leukotriene B4
  • 12-oxoleukotriene B4
  • 12(S)-Leukotriene B4
  • 20-oxoleukotriene B4
  • 5-Methyl-3-(piperidin-3-yl)-3,4-dihydroquinazolin-4-one
  • 3-(Piperidin-3-yl)-6-(trifluoromethyl)-3,4-dihydroquinazolin-4-one
  • 6-Methyl-3-(piperidin-3-yl)-3,4-dihydroquinazolin-4-one
  • 6-Bromo-3-(piperidin-3-yl)-3,4-dihydroquinazolin-4-one
  • 6-Methoxy-3-(piperidin-3-yl)-3,4-dihydroquinazolin-4-one
  • 1-(1-Aminocyclopentyl)but-3-yn-1-one
  • 1-(1-Aminocyclopentyl)butan-1-one
  • 1-(1-Aminocyclopentyl)prop-2-EN-1-one
  • 1-(1-Aminocyclopentyl)-2-methylprop-2-en-1-one
  • 1-(Cyclopentylamino)but-3-en-2-one
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