1,3-Piperidinedicarboxylicacid 1-tert-butyl ester

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Names

[ CAS No. ]:
71381-75-4

[ Name ]:
1,3-Piperidinedicarboxylicacid 1-tert-butyl ester

[Synonym ]:
BOC-DL-PIC(3)-OH
(s)-boc-nip-oh
rac-N-(t-butoxycarbonyl)piperidine-3-carboxylic acid
N-(tert-butyloxy-carbonyl)piperidine-3-carboxylic acid
(S)-BOC-NIP
(RS)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester
BOC-NIP-OH
N-BOC-nipecotic acid
BOC-NIP
BOC-(S)-NIP-OH
piperidine-1,3-dicarboxylic acid 1-tert-butyl ester
N-tert-butoxycarbonyl-3-piperidinecarboxylic acid
1-(tert-butoxycarbonyl)-3-piperidine carboxylic acid
MFCD00673775
BOC-L-NIP-OH
BOC-DL-NIPC-OH
BOC-(R,S)-NIP-OH
BOC-DL-NIP-OH

Chemical & Physical Properties

[ Melting Point ]:
159-162ºC(lit.)

[ Molecular Formula ]:
C11H19NO4

[ Molecular Weight ]:
229.27300

[ Exact Mass ]:
229.13100

[ PSA ]:
66.84000

[ LogP ]:
1.65600

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Di-tert-butyl dicarbonate
  • Nipecotic acid
  • BOC-ON
  • (S)-3-piperidinecarboxylic acid*HCl
  • 2-[[(tert-butoxycarbonyl)oxy]imino]-2-phenylacetonitrile
  • Triethylamine
  • tert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate
  • ethyl nipecotate

DownStream

  • 4-Piperidinyl(1-pyrrolidinyl)methanone
  • N-Boc-3-Cyanopiperidine
  • 1-Piperidinyl(3-piperidinyl)methanone
  • Methyl piperidine-3-carboxylate
  • 1-Boc-3-Carbamoylpiperidine
  • tert-butyl 3-isocyanatopiperidine-1-carboxylate
  • 1-N-BOC-3-CBZ-AMINO-PIPERIDINE
  • 6-oxopiperidine-3-carboxylic acid
  • 3-Acetyl-1-piperidinecarboxylic acid tert-butyl ester
  • 3-(1H-Benzimidazol-2-yl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Related Compounds

  • Azepane-1,3-dicarboxylic acid 1-tert-butyl ester
  • 3-Fluoro-1,3-piperidinedicarboxylic acid 1-tert-butyl ester
  • 2-Methyl-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester
  • 4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
  • 4-BENZYL-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
  • 3-Benzyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester