Plinabulin (NPI-2358)

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Names

[ Name ]:
Plinabulin (NPI-2358)

[Synonym ]:
NPI-2358/KPU-2
Plinabulin,NPI2358,NPI-2358
Plinabulin
2,5-Piperazinedione, 3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)-, (3Z,6Z)-
S1176_Selleck
Plinabulin,NPI2358
NPI 2358
Plinabulin [USAN:INN]
(3Z,6Z)-3-Benzylidene-6-{[4-(2-methyl-2-propanyl)-1H-imidazol-5-yl]methylene}-2,5-piperazinedione
3-Z-benzylidene-6-(5"-tert-butyl-1H-imidazol-4"-Z-ylmethylene)-piperazine-2,5-dione
3-(Z)-benzylidene-6-(((Z)-5-tert-butyl-1H-imidazol-4-yl)methylene)-piperazine-2,5-dione
tert-butyl-dehydrophenylahistin

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
730.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₀N₄O₂

[ Molecular Weight ]:
336.388

[ Flash Point ]:
395.5±32.9 °C

[ Exact Mass ]:
336.158630

[ PSA ]:
94.92000

[ LogP ]:
2.66

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.657

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,5-Piperazinedione, 1-acetyl-3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-, (3Z)-
Benzaldehyde
5-(tert-Butyl)-1H-imidazole-4-carbaldehyde
(((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate
ethyl 4,4,4-trimethylacetoacetate
5-(1,1-Dimethylethyl)-1H-imidazole-4-methanol