3-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]propanoic acid

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Names

[ CAS No. ]:
71576-05-1

[ Name ]:
3-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]propanoic acid

[Synonym ]:
3-[[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]CARBAMOYL]PROPANOIC ACID
4-((4-(4-Chlorophenyl)-2-thiazolyl)amino)-4-oxobutanoic acid
4-{[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino}-4-oxobutanoic acid
Butanoic acid,4-((4-(4-chlorophenyl)-2-thiazolyl)amino)-4-oxo
Acide N(p-chlorophenyl-4 thiazolyl-2) succinamique [French]
F 1683
4-(4-(4-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoic acid

Chemical & Physical Properties

[ Density]:
1.479g/cm3

[ Molecular Formula ]:
C13H11ClN2O3S

[ Molecular Weight ]:
310.75600

[ Exact Mass ]:
310.01800

[ PSA ]:
111.02000

[ LogP ]:
3.91630

[ Index of Refraction ]:
1.657

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EK7761172
CHEMICAL NAME :
Butanoic acid, 4-((4-(4-chlorophenyl)-2-thiazolyl)amino)-4-oxo-
CAS REGISTRY NUMBER :
71576-05-1
LAST UPDATED :
199609
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H11-Cl-N2-O3-S
MOLECULAR WEIGHT :
310.77

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0001727

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Succinic anhydride
  • 2-amino-4-(4-chlorophenyl)thiazole
  • 1-(4-Chlorophenyl)ethanone
  • 2-Bromo-4'-chloroacetophenone

DownStream

Related Compounds

  • N8-[(2H-1,3-benzodioxol-5-yl)methyl]-5-oxo-N3-[(oxolan-2-yl)methyl]-1-sulfanylidene-1H,4H,5H-[1,3]thiazolo[3,4-a]quinazoline-3,8-dicarboxamide
  • 7-Benzyl-8-(2-ethoxyethylsulfanyl)-3-methyl-4,5-dihydropurine-2,6-dione
  • 1-(2-fluorophenyl)-2-(3-hydroxypropyl)-4a,5,6,7,8,8a-hexahydro-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 4-(8-Chlorochroman-4-yl)-N-(pyridazin-3-yl)piperazine-1-carboxamide
  • 7-chloro-1-(3-methoxy-4-phenylmethoxyphenyl)-2-(1,3-thiazol-2-yl)-4a,5,6,7,8,8a-hexahydro-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 1-(4-hexoxyphenyl)-2-(6-methylpyridin-2-yl)-4a,5,6,7,8,8a-hexahydro-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 8-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1,3-dimethyl-7-(3-methylbutyl)-5H-purin-7-ium-2,6-dione
  • 6-(4-Bromophenyl)-4,7-dimethyl-4a,9a-dihydropurino[7,8-a]imidazole-1,3-dione
  • (R)-1-((2-chlorothiazol-5-yl)methyl)piperidin-3-ol
  • 5,5'-Diformyl-3,3'-dimethoxy-[1,1'-biphenyl]-2,2'-diyl diacetate
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