3-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]propanoic acid

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Names

[ CAS No. ]:
71576-05-1

[ Name ]:
3-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]propanoic acid

[Synonym ]:
3-[[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]CARBAMOYL]PROPANOIC ACID
4-((4-(4-Chlorophenyl)-2-thiazolyl)amino)-4-oxobutanoic acid
4-{[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino}-4-oxobutanoic acid
Butanoic acid,4-((4-(4-chlorophenyl)-2-thiazolyl)amino)-4-oxo
Acide N(p-chlorophenyl-4 thiazolyl-2) succinamique [French]
F 1683
4-(4-(4-chlorophenyl)thiazol-2-ylamino)-4-oxobutanoic acid

Chemical & Physical Properties

[ Density]:
1.479g/cm3

[ Molecular Formula ]:
C13H11ClN2O3S

[ Molecular Weight ]:
310.75600

[ Exact Mass ]:
310.01800

[ PSA ]:
111.02000

[ LogP ]:
3.91630

[ Index of Refraction ]:
1.657

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EK7761172
CHEMICAL NAME :
Butanoic acid, 4-((4-(4-chlorophenyl)-2-thiazolyl)amino)-4-oxo-
CAS REGISTRY NUMBER :
71576-05-1
LAST UPDATED :
199609
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H11-Cl-N2-O3-S
MOLECULAR WEIGHT :
310.77

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0001727

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Succinic anhydride
  • 2-amino-4-(4-chlorophenyl)thiazole
  • 1-(4-Chlorophenyl)ethanone
  • 2-Bromo-4'-chloroacetophenone

DownStream

Related Compounds

  • 2-{[7-(5-Bromopyridin-2-yl)-2-[(tert-butoxy)carbonyl]-5-oxa-2-azaspiro[3.4]octan-7-yl]oxy}acetic acid
  • 2-({7-[(Benzyloxy)carbonyl]-2-(5-bromopyridin-2-yl)-7-azaspiro[4.5]decan-2-yl}oxy)acetic acid
  • 2-{[4-(3-Bromophenyl)-1-[(tert-butoxy)carbonyl]azepan-4-yl]oxy}acetic acid
  • 2-{[3-(3-bromophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}azetidin-3-yl]oxy}acetic acid
  • 3-Fluoro-2-(hydroxymethyl)-8-methoxy-6-quinolinecarboxylic acid
  • 4-(4-bromophenyl)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-3-carboxylic acid
  • 2-(6-bromo-1H-1,2,3-benzotriazol-1-yl)-3-methylbutan-1-ol
  • 6-bromo-1-(3-methoxypropyl)-1H-1,2,3-benzotriazole
  • tert-butyl(3S)-3-isothiocyanatopyrrolidine-1-carboxylate
  • Sodium 2-(3-iodo-4-methoxyphenoxy)propanoate
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