Nafcillin sodium salt monohydrate

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Names

[ CAS No. ]:
7177-50-6

[ Name ]:
Nafcillin sodium salt monohydrate

[Synonym ]:
nafcillin sodium monohydrate
MFCD01941128
Nafcillin sodium salt monohydrate
NAFCILLINSODIUMSTERILE
nafcillin sodium
Unipen (tn)
Sodium (2S,5R,6R)-6-[(2-ethoxy-1-naphthoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate (1:1:1)
Nafcillin monohydrate sodium salt
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, (2S,5R,6R)-, hydrate (1:1:1)
Nafcillin (sodium monohydrate)

Chemical & Physical Properties

[ Density]:
1.42 g/cm3

[ Boiling Point ]:
714.1ºC at 760 mmHg

[ Molecular Formula ]:
C21H23N2NaO6S

[ Molecular Weight ]:
454.472

[ Flash Point ]:
385.7ºC

[ Exact Mass ]:
454.117462

[ PSA ]:
133.30000

[ LogP ]:
1.41360

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H317-H319-H334-H335

[ Precautionary Statements ]:
P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Effect of NaCl and nafcillin on penicillin-binding protein 2a and heterogeneous expression of methicillin resistance in Staphylococcus aureus.

Antimicrob. Agents Chemother. 31 , 1982-1988, (1987)

Expression of methicillin resistance in heterogeneous strains of Staphylococcus aureus is enhanced by 2 to 5% NaCl in the medium and by selection with beta-lactam antibiotics. Resistance is associated...

Co-trimoxazole versus nafcillin in the therapy of experimental meningitis due to Staphylococcus aureus.

J. Antimicrob. Chemother. 19 , 647-658, (1987)

Co-trimoxazole was compared with nafcillin against Staphylococcus aureus in vitro and in the therapy of experimental Staph. aureus meningitis in rabbits. Co-trimoxazole (trimethoprim:sulphamethoxazole...


More Articles

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