Substance P (free acid)

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Names

[ CAS No. ]:
71977-09-8

[ Name ]:
Substance P (free acid)

[Synonym ]:
H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OH
RPKPQQFFGLM
H-RPKPQQFFGLM-OH
RPKPQQFFGLM-OH
[Met-OH11] substance P
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
Substance P, free acid

Chemical & Physical Properties

[ Density]:
1.41 g/cm3

[ Molecular Formula ]:
C63H97N17O14S

[ Molecular Weight ]:
1348.61000

[ Exact Mass ]:
1347.71000

[ PSA ]:
536.14000

[ LogP ]:
4.09310

[ Storage condition ]:
2-8℃

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Boc-Gly-OH
  • Boc-Leu-OH.H2O
  • Boc-Met-OH
  • Boc-L-phenylalanine

DownStream

Articles

Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.

Int. J. Pept. Protein Res. 41 , 411-414, (1993)

Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. ...

Synthesis of peptides by the solid-phase method. 7. Substance P and analogues.

J. Med. Chem. 25 , 64, (1982)

Substance P and 21 related peptides containing isosteric or isofunctional groups were prepared by the solid-phase method. After purification by gel filtration and ion-exchange chromatography, the comp...

Biological activity of substance P methyl ester.

Mol. Pharmacol. 20 , 457, (1981)


More Articles

Related Compounds

  • substance P (6-11), Glu(6)-
  • substance P (6-11), Orn(6)-
  • Substance P (1-7)
  • substance P, aminoethyl(2)-Met(11)-
  • substance p
  • substance P, Phe(7)-
  • 8-amino-7-[(E)-but-2-enyl]-1,3-dimethyl-5H-purin-7-ium-2,6-dione
  • 3-(5-Methylpyrazin-2-yl)oxolane-2,5-dione
  • 2-[4-[(4-Methylphenyl)methyl]-2,3-dioxopiperazin-1-yl]acetamide
  • 5-But-3-enyl-2-(3-methoxyphenyl)-1,2,3,3a-tetrahydropyrazolo[1,5-a]pyrazin-4-one
  • (6-Cyclopentylpyrimidin-4-yl)methanol
  • 3-[(3-Aminopropyl)sulfanyl]-2,2-difluoropropanoic acid
  • (6-Cyclohexylpyrimidin-4-yl)methanol
  • (1R)-2,2,2-trifluoro-1-(8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-ol
  • 2,2-Difluoro-3-[(3-hydroxypropyl)sulfanyl]propanoic acid
  • Ethyl 2,2-difluoro-3-(prop-2-en-1-ylsulfanyl)propanoate
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