Substance P (free acid)

Suppliers

Names

[ CAS No. ]:
71977-09-8

[ Name ]:
Substance P (free acid)

[Synonym ]:
H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OH
RPKPQQFFGLM
H-RPKPQQFFGLM-OH
RPKPQQFFGLM-OH
[Met-OH11] substance P
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
Substance P, free acid

Chemical & Physical Properties

[ Density]:
1.41 g/cm3

[ Molecular Formula ]:
C₆₃H₉₇N₁₇O₁₄S

[ Molecular Weight ]:
1348.61000

[ Exact Mass ]:
1347.71000

[ PSA ]:
536.14000

[ LogP ]:
4.09310

[ Storage condition ]:
2-8℃

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Boc-Gly-OH
Boc-Leu-OH.H2O
Boc-Met-OH
Boc-L-phenylalanine

DownStream

Articles

Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.

Int. J. Pept. Protein Res. 41 , 411-414, (1993)

Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. ...

Synthesis of peptides by the solid-phase method. 7. Substance P and analogues.

J. Med. Chem. 25 , 64, (1982)

Substance P and 21 related peptides containing isosteric or isofunctional groups were prepared by the solid-phase method. After purification by gel filtration and ion-exchange chromatography, the comp...

Biological activity of substance P methyl ester.

Mol. Pharmacol. 20 , 457, (1981)

substance P (6-11), Glu(6)-
substance P (6-11), Orn(6)-
Substance P (1-7)
substance P, aminoethyl(2)-Met(11)-
substance p
substance P, Phe(7)-
8-{[(9H-fluoren-9-yl)methoxy]carbonyl}-2-oxa-8-azaspiro[4.5]decane-3-carboxylic acid
2-Chloro-4-methoxy-1-(prop-2-yn-1-yl)benzene
(9H-fluoren-9-yl)methyl (7S,8aS)-7-hydroxy-octahydropyrrolo[1,2-a]pyrazine-2-carboxylate
(9H-fluoren-9-yl)methyl N-(6-cyclopropanecarbonylpyridin-2-yl)carbamate
2-{[(Tert-butoxy)carbonyl]amino}-6-(methoxycarbonyl)pyridine-3-carboxylic acid
(2S)-3-(4-{[(benzyloxy)carbonyl]amino}phenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
(9H-fluoren-9-yl)methyl N-(oct-7-yn-1-yl)carbamate
benzyl N-{4-[(prop-2-en-1-yl)carbamoyl]phenyl}carbamate
1-Cyclopropyl-3-(prop-2-yn-1-yl)benzene
benzyl N-(5-bromo-1-ethynyl-2,3-dihydro-1H-inden-1-yl)carbamate

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