Substance P (free acid)

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Names

[ CAS No. ]:
71977-09-8

[ Name ]:
Substance P (free acid)

[Synonym ]:
H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OH
RPKPQQFFGLM
H-RPKPQQFFGLM-OH
RPKPQQFFGLM-OH
[Met-OH11] substance P
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
Substance P, free acid

Chemical & Physical Properties

[ Density]:
1.41 g/cm3

[ Molecular Formula ]:
C63H97N17O14S

[ Molecular Weight ]:
1348.61000

[ Exact Mass ]:
1347.71000

[ PSA ]:
536.14000

[ LogP ]:
4.09310

[ Storage condition ]:
2-8℃

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Boc-Gly-OH
  • Boc-Leu-OH.H2O
  • Boc-Met-OH
  • Boc-L-phenylalanine

DownStream

Articles

Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.

Int. J. Pept. Protein Res. 41 , 411-414, (1993)

Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. ...

Synthesis of peptides by the solid-phase method. 7. Substance P and analogues.

J. Med. Chem. 25 , 64, (1982)

Substance P and 21 related peptides containing isosteric or isofunctional groups were prepared by the solid-phase method. After purification by gel filtration and ion-exchange chromatography, the comp...

Biological activity of substance P methyl ester.

Mol. Pharmacol. 20 , 457, (1981)


More Articles

Related Compounds

  • substance P (6-11), Glu(6)-
  • substance P (6-11), Orn(6)-
  • Substance P (1-7)
  • substance P, aminoethyl(2)-Met(11)-
  • substance p
  • substance P, Phe(7)-
  • 3-(1-ethenyl-1H-pyrazol-4-yl)-2-hydroxypropanoic acid
  • 2-Hydroxy-3-(2-methoxypyridin-4-yl)-3-methylbutanoic acid
  • 5-(3,3-Dimethylcyclohexyl)-1,2-oxazole-4-carboxylic acid
  • 2,2-Dimethyl-3-{pyrazolo[1,5-a]pyrimidin-6-yl}propanoic acid
  • 2-Hydroxy-2-methyl-3-(pyrazin-2-yl)propanoic acid
  • 2-hydroxy-2-(1-methyl-3-phenyl-1H-pyrazol-5-yl)acetic acid
  • (3R)-3-(1-ethyl-1H-imidazol-5-yl)-3-hydroxypropanoic acid
  • 2-Fluoro-1-[2-(trifluoromethoxy)phenyl]ethan-1-ol
  • 3-{1H,4H,5H,6H-cyclopenta[c]pyrazol-3-yl}-2-methoxypropanoic acid
  • 1-(3,4-dihydro-2H-pyran-5-yl)cyclohexane-1-carboxylic acid
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