L-Valine

Names

[ CAS No. ]:
72-18-4

[ Name ]:
L-Valine

[Synonym ]:
H-L-VAL-OH
L-Val
L-(S)-valine
MFCD00064220
EINECS 200-773-6
2-aminoisovaleric acid
VALINE,L
L-Valine
L-Val-OH
L-VLA
Valin
H-VAL-OH

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
213.6±23.0 °C at 760 mmHg

[ Melting Point ]:
315ºC

[ Molecular Formula ]:
C₅H₁₁NO₂

[ Molecular Weight ]:
117.146

[ Flash Point ]:
83.0±22.6 °C

[ Exact Mass ]:
117.078979

[ PSA ]:
63.32000

[ LogP ]:
0.20

[ Vapour Pressure ]:
0.1±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.461

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV9361000

CHEMICAL NAME :: Valine, L-

CAS REGISTRY NUMBER :: 72-18-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C5-H11-N-O2

MOLECULAR WEIGHT :: 117.17

WISWESSER LINE NOTATION :: QVYZY1&1 -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5390 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81870 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 882 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81870 No. of Facilities: 811 (estimated) No. of Industries: 4 No. of Occupations: 16 No. of Employees: 19343 (estimated) No. of Female Employees: 14342 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YV9361000

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-Butenoicacid,2-(1,1-dimethylethoxy)carbonylamino-3-methyl-,(2S)-(9ci)
α-Ketoisovaleric acid
Proc-Val-OH
3-methyl-2-oxobutanoate
Fmoc-Val-OMe
2-benzamido-3-methyl-but-2-enoic acid
DL-Valine

DownStream

h-ala-val-ome hcl
1-Butanol,2-[bis(phenylmethyl)amino]-3-methyl-, (2S)-
((4-methoxyphenyl)carbonyl)-valyl-N-(3-(1,1,1-trifluoro-2-hydroxy-4-methylpentyl))prolinamide
(S)-tert-Butyl 2-hydroxy-3-methylbutanoate
Ethyl L-valinate hydrochloride (1:1)
N2-(tert-Butoxycarbonyl)-L-valinamide
H-Val-Val-OH
Leu-Leu
H-Val-Val-Val-OH
H-Leu-Leu-Leu-OH

Customs

[ HS Code ]: 29224995

Articles

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Bee pollen improves muscle protein and energy metabolism in malnourished old rats through interfering with the Mtor signaling pathway and mitochondrial activity.

Nutrients 6(12) , 5500-16, (2014)

Although the management of malnutrition is a priority in older people, this population shows a resistance to refeeding. Fresh bee pollen contains nutritional substances of interest for malnourished pe...

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

D,L-Valine
L-Valine-d8
L-Valine-1-C
DNP-L-valine
l-valine-2-d1
L-Valine-13C5
5-bromo-2-isopropylpyridazin-3(2H)-one
4-[(3-Chlorophenyl)methyl]-1,1-dioxothian-4-amine
6-Chloro-2H-spiro[1-benzofuran-3,4'-piperidine]
3-(Difluoromethyl)-1-((4-(trifluoromethyl)phenyl)sulfonyl)azetidine
1-(difluoromethyl)-N-[(1-ethyl-5-fluoro-1H-pyrazol-4-yl)methyl]-3-methyl-1H-pyrazol-4-amine
[(1,5-dimethyl-1H-pyrazol-4-yl)methyl][(1-ethyl-5-fluoro-3-methyl-1H-pyrazol-4-yl)methyl]amine
[(1-ethyl-5-fluoro-3-methyl-1H-pyrazol-4-yl)methyl][(1-propyl-1H-pyrazol-3-yl)methyl]amine
N-[(1-ethyl-5-fluoro-3-methyl-1H-pyrazol-4-yl)methyl]-1-(propan-2-yl)-1H-pyrazol-5-amine
1-((3-Chlorophenyl)sulfonyl)-3-(difluoromethyl)azetidine
1-((2,4-Dichloro-5-methylphenyl)sulfonyl)-3-(difluoromethyl)azetidine

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