1,4-Bis(3-aminopropyl)piperazine

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Names

[ CAS No. ]:
7209-38-3

[ Name ]:
1,4-Bis(3-aminopropyl)piperazine

[Synonym ]:
MFCD00006161
1,4-Piperazinedipropanamine
3,3'-(1,4-Piperazinediyl)di(1-propanamine)
EINECS 230-589-1
1,4-Bis(3-aminopropyl)piperazine
3,3'-PIPERAZINE-1,4-DIYLDIPROPAN-1-AMINE
BAPPRZ
BIS AMINOPROPYL PIPIRAZINE

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
334.5±0.0 °C at 760 mmHg

[ Melting Point ]:
15 °C(lit.)

[ Molecular Formula ]:
C10H24N4

[ Molecular Weight ]:
200.324

[ Flash Point ]:
162.8±0.0 °C

[ Exact Mass ]:
200.200104

[ PSA ]:
58.52000

[ LogP ]:
-1.43

[ Vapour density ]:
6.9 (vs air)

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.505

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
TK8700000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N,N'-bis(3-((tert-butyloxycarbonyl)amino)propyl)piperazine
  • piperazine-1,4-dipropiononitrile
  • Piperazine
  • Acrylonitrile
  • N,N'-Bis(3-aminopropyl)-1,2-ethanediamine

DownStream

  • 3-phenyl-1-[3-[4-[3-(phenylthiocarbamoylamino)propyl]piperazin-1-yl]propyl]thiourea
  • N-[3-[4-(3-aminopropyl)piperazin-1-yl]propyl]-9-methoxy-5-methyl-6H-pyrido[4,3-b]carbazol-1-amine
  • 6-[[3-[4-[3-[(6-oxo-1-cyclohexa-2,4-dienylidene)methylamino]propyl]piperazin-1-yl]propylamino]methylidene]cyclohexa-2,4-dien-1-one
  • 2-(2,4,6-trimethylphenoxy)-N-[3-[4-[3-[[2-(2,4,6-trimethylphenoxy)acetyl]amino]propyl]piperazin-1-yl]propyl]acetamide,dihydrochloride
  • 1,5,13,17,22-pentaazatricyclo[15.2.2.17,11]docosa-7,9,11(22)-triene-6,12-dione

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Multifunctional disulfide-based cationic dextran conjugates for intravenous gene delivery targeting ovarian cancer cells.

Mol. Pharm. 11(7) , 2250-61, (2014)

A folate-decorated, disulfide-based cationic dextran conjugate having dextran as the main chain and disulfide-linked 1,4-bis(3-aminopropyl)piperazine (BAP) residues as the grafts was designed and succ...

Thermodynamic Investigation and Mixed Ligand Complex Formation of 1,4-Bis-(3-aminopropyl)-piperazine and Biorelevant Ligands.

Bioinorg. Chem. Appl. 2012 , 984291, (2012)

Thermodynamic parameters for protonation of 1,4-bis(3-aminopropyl)-piperazine (BAPP) and its metal complexation with some divalent metal ions were determined in aqueous solution at constant ionic stre...

Multifunctional cationic polyurethanes designed for non-viral cancer gene therapy.

Acta Biomater. 30 , 155-67, (2015)

Nano-polyplexes from bioreducible cationic polymers have a massive promise for cancer gene therapy. However, the feasibility of cationic polyurethanes for non-viral gene therapy is so far not well stu...


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Related Compounds

  • 1,4-BIS-(3-AMINOPROPYL)-PIPERAZINE
  • 1,4-Bis(3-aminopropyl)piperazine adipate (1:1)
  • N-tert-butoxycarbonyl-1,4-bis(3-aminopropyl)piperazine
  • 1,4-bis(3-aminopropyl)piperazin-2-one
  • 1,4-Bis(3-isocyanopropyl)piperazine
  • 1,4-Bis(3-chlorophenyl)piperazine
  • 2-((6-(4-chlorobenzyl)-2-ethyl-7-oxo-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-5-yl)thio)-N-(2-methoxyphenyl)acetamide
  • 2-({6-[(4-chlorophenyl)methyl]-2-ethyl-7-oxo-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-5-yl}sulfanyl)-N-(2-ethylphenyl)acetamide
  • 2-((6-(4-chlorobenzyl)-2-ethyl-7-oxo-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-5-yl)thio)-N-(4-methoxyphenyl)acetamide
  • 2-({6-[(4-chlorophenyl)methyl]-2-ethyl-7-oxo-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-5-yl}sulfanyl)-N-(2,4-dimethylphenyl)acetamide
  • 2-({6-[(4-chlorophenyl)methyl]-2-ethyl-7-oxo-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-5-yl}sulfanyl)-N-(3,5-dimethylphenyl)acetamide
  • 6-(4-chlorobenzyl)-2-ethyl-5-((2-fluorobenzyl)thio)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
  • 6-(4-chlorobenzyl)-2-ethyl-5-((3-fluorobenzyl)thio)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
  • N-benzyl-2-({2-ethyl-6-[(4-methoxyphenyl)methyl]-7-oxo-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-5-yl}sulfanyl)acetamide
  • N-(4-ethoxyphenyl)-2-((2-ethyl-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-5-yl)thio)acetamide
  • N-(2-chlorobenzyl)-2-((2-ethyl-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-5-yl)thio)acetamide
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