1-(2-Pyridinyl)-4-(4-((7-(trifluoromethyl)-4-quinolinyl)amino)benzoyl) piperazine

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Names

[ CAS No. ]:
72141-45-8

[ Name ]:
1-(2-Pyridinyl)-4-(4-((7-(trifluoromethyl)-4-quinolinyl)amino)benzoyl) piperazine

Chemical & Physical Properties

[ Density]:
1.364g/cm3

[ Boiling Point ]:
652.7ºC at 760 mmHg

[ Molecular Formula ]:
C26H22F3N5O

[ Molecular Weight ]:
477.48100

[ Flash Point ]:
348.5ºC

[ Exact Mass ]:
477.17800

[ PSA ]:
61.36000

[ LogP ]:
5.43050

[ Index of Refraction ]:
1.652

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM2765200
CHEMICAL NAME :
Piperazine, 1-(2-pyridinyl)-4-(4-((7-(trifluoromethyl)-4-quinolin yl)amino)benzoyl)-
CAS REGISTRY NUMBER :
72141-45-8
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C26-H22-F3-N5-O
MOLECULAR WEIGHT :
477.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1395 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,133,1986

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Chloropyridine
  • Piperazine, 1-(4-((7-(trifluoromethyl)-4-quinolinyl)amino)benzoyl)-

DownStream

Related Compounds

  • 2-{4-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoyl]morpholin-2-yl}acetic acid
  • 4-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoyl]-2-methylmorpholine-3-carboxylic acid
  • 5-{[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanamido]methyl}oxolane-2-carboxylic acid
  • 4-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methyl-N-(propan-2-yl)pentanamido]butanoic acid
  • 1-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopropanecarbonyl}-1H,2H,3H-pyrazolo[1,5-a]imidazole-7-carboxylic acid
  • 2-{1-[1-benzyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyrrolidine-3-carbonyl]piperidin-2-yl}acetic acid
  • 2-(1-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]butanoyl}piperidin-2-yl)acetic acid
  • 2-{1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoyl]piperidin-2-yl}acetic acid
  • 2-{1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hex-5-enoyl]piperidin-2-yl}acetic acid
  • 2-cyclopropyl-2-{2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1H-pyrazol-1-yl]acetamido}propanoic acid
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