Losulazine

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Names

[ CAS No. ]:
72141-57-2

[ Name ]:
Losulazine

[Synonym ]:
Losulazina
Losulazine
Losulazinum

Chemical & Physical Properties

[ Density]:
1.454g/cm3

[ Boiling Point ]:
695.7ºC at 760 mmHg

[ Molecular Formula ]:
C27H22F4N4O3S

[ Molecular Weight ]:
558.54700

[ Flash Point ]:
374.5ºC

[ Exact Mass ]:
558.13500

[ PSA ]:
90.99000

[ LogP ]:
6.31260

[ Index of Refraction ]:
1.638

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM0829800
CHEMICAL NAME :
Piperazine, 1-((4-fluorophenyl)sulfonyl)-4-(4-((7-(trifluoromethy l)-4-quinolinyl)amino) benzoyl)-
CAS REGISTRY NUMBER :
72141-57-2
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C27-H22-F4-N4-O3-S
MOLECULAR WEIGHT :
558.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,133,1986 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
168 mg/kg
SEX/DURATION :
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 33,36C,1986

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • chloro(4-fluorophenyl)sulfone
  • Piperazine, 1-(4-((7-(trifluoromethyl)-4-quinolinyl)amino)benzoyl)-

DownStream

Related Compounds

  • Losulazine
  • N1-(o-tolyl)-N2-(2-(1-tosylpiperidin-2-yl)ethyl)oxalamide
  • N1-(3,4-dimethylphenyl)-N2-(2-(1-tosylpiperidin-2-yl)ethyl)oxalamide
  • N1-(2,4-dimethylphenyl)-N2-(2-(1-tosylpiperidin-2-yl)ethyl)oxalamide
  • N1-(2,5-dimethylphenyl)-N2-(2-(1-tosylpiperidin-2-yl)ethyl)oxalamide
  • N-{2-[1-(4-methylbenzenesulfonyl)piperidin-2-yl]ethyl}-N'-[(2-methylphenyl)methyl]ethanediamide
  • N1-(4-methoxyphenyl)-N2-(2-(1-((4-methoxyphenyl)sulfonyl)piperidin-2-yl)ethyl)oxalamide
  • N1-(4-chlorophenyl)-N2-(2-(1-((4-methoxyphenyl)sulfonyl)piperidin-2-yl)ethyl)oxalamide
  • N-{2-[1-(4-methoxybenzenesulfonyl)piperidin-2-yl]ethyl}-N'-(4-methylphenyl)ethanediamide
  • N1-(3-chlorophenyl)-N2-(2-(1-((4-methoxyphenyl)sulfonyl)piperidin-2-yl)ethyl)oxalamide
  • N1-(2-(1-((4-methoxyphenyl)sulfonyl)piperidin-2-yl)ethyl)-N2-(m-tolyl)oxalamide
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