Barasertib (AZD1152-HQPA)

Suppliers

Names

[ Name ]:
Barasertib (AZD1152-HQPA)

[Synonym ]:
AZD1152-HQPA
INH 34
AZD-1152-HQPA
2-{3-[(7-{3-[Ethyl(2-hydroxyethyl)amino]propoxy}-4-quinazolinyl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide
Barasertib
2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide
1H-Pyrazole-5-acetamide, 3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-
AZD1152 HPQA

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
796.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₀FN₇O₃

[ Molecular Weight ]:
507.560

[ Flash Point ]:
435.6±32.9 °C

[ Exact Mass ]:
507.239410

[ PSA ]:
128.29000

[ LogP ]:
2.82

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.677

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: >15mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-(5-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(3-fluorophenyl)acetamide
2-(Ethylamino)ethanol
1H-pyrazole-3-acetic acid, 5-amino-
7-(3-Hydroxypropoxy)-4(1H)-quinazolinone
7-(3-CHLOROPROPOXY)-4-CHLOROQUINAZOLINE
[5-[7-(3-Chloropropoxy)quinazolin-4-ylamino]pyrazol-3-yl]acetic acid
7-fluoro quinazolin-4-ol

DownStream

Articles

MicroRNA let-7b regulates genomic balance by targeting Aurora B kinase.

Mol. Oncol. 9 , 1056-70, (2015)

The let-7 microRNA (miRNA) family has been implicated in the regulation of diverse cellular processes and disease pathogenesis. In cancer, loss-of-function of let-7 miRNAs has been linked to tumorigen...

The novel function of JADE1S in cytokinesis of epithelial cells.

Cell Cycle 14 , 2821-34, (2015)

JADE1 belongs to a small family of PHD zinc finger proteins that interacts with histone acetyl transferase (HAT) HBO1 and is associated with chromatin. We recently reported JADE1 chromatin shuttling a...

Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA.

Mol. Neurobiol. 53 , 1808-23, (2016)

Aurora kinase B (AURKB), a crucial regulator of malignant mitosis, is involved in chromosome segregation and cytokinesis. AZD1152-HQPA is a selective inhibitor for AURKB activity and currently bears c...

Azelaic acid
AZD1152
5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide dihydrochloride
di-tert-butyl 2-[[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl](ethyl)amino]ethyl phosphate
2-Amino-1-[2-(dimethylamino)pyridin-3-yl]ethan-1-one
2-(3-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3,3-trifluoropropanamido]methyl}cyclobutyl)acetic acid
(2R)-1-{2-[(1RS,3SR)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]acetyl}-2-methylpyrrolidine-2-carboxylic acid
rac-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{[(3R,4S)-4-methyl-1,1-dioxo-1lambda6-thiolan-3-yl]carbamoyl}propanoic acid
2-(N-benzyl-1-{4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}formamido)acetic acid
rac-(1R,3S)-3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-methylhex-4-enamido]cyclopentane-1-carboxylic acid
2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-methylhex-4-enoyl]-2-azabicyclo[2.1.1]hexane-5-carboxylic acid
3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-methylhex-4-enoyl]-3-azabicyclo[3.1.0]hexane-1-carboxylic acid
2-Ethoxy-4-fluoro-1-(3-methylbut-2-en-2-yl)benzene
2-(2-{[(Tert-butoxy)carbonyl]amino}phenyl)butanedioic acid

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