(-)-Trofosphamide

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Names

[ CAS No. ]:
72282-84-9

[ Name ]:
(-)-Trofosphamide

[Synonym ]:
8-Tetrahydro Cannabinol

Chemical & Physical Properties

[ Density]:
1.356g/cm3

[ Boiling Point ]:
393.71ºC at 760 mmHg

[ Molecular Formula ]:
C9H18Cl3N2O2P

[ Molecular Weight ]:
323.58400

[ Flash Point ]:
191.909ºC

[ Exact Mass ]:
322.01700

[ PSA ]:
42.59000

[ LogP ]:
2.77310

[ Index of Refraction ]:
1.519

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP5789200
CHEMICAL NAME :
2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (R)-
CAS REGISTRY NUMBER :
72282-84-9
LAST UPDATED :
198812
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H18-Cl3-N2-O2-P
MOLECULAR WEIGHT :
323.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
820 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.10- 1962- Volume(issue)/page/year: 34,305,1986

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-[bis-(2-chloro-ethyl)-amino]-3-chloroacetyl-[1,3,2]oxazaphosphinane (S)-2-oxide
  • (R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
  • bis-(2-chloro-ethyl)-[(R)-3-((S)-1-naphthalen-1-yl-ethyl)-2-oxo-2λ5-[1,3,2]oxazaphosphinan-2-yl]-amine

DownStream