1-phenylisatin

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Names

[ CAS No. ]:
723-89-7

[ Name ]:
1-phenylisatin

[Synonym ]:
n-phenylisatin
1-Phenylisatin
MFCD00082681
1H-Indole-2,3-dione,1-phenyl
1-Phenyl-indole-2,3-dione
INDOLE-2,3-DIONE,1-PHENYL
1-Phenylindoline-2,3-dione
N-phenylindoline-2,3-dione

Chemical & Physical Properties

[ Density]:
1.338g/cm3

[ Boiling Point ]:
388.8ºC at 760 mmHg

[ Melting Point ]:
138-140 °C(lit.)

[ Molecular Formula ]:
C14H9NO2

[ Molecular Weight ]:
223.22700

[ Flash Point ]:
182.6ºC

[ Exact Mass ]:
223.06300

[ PSA ]:
37.38000

[ LogP ]:
2.61260

[ Index of Refraction ]:
1.667

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL7984000
CHEMICAL NAME :
Indole-2,3-dione, 1-phenyl-
CAS REGISTRY NUMBER :
723-89-7
BEILSTEIN REFERENCE NO. :
0164531
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H9-N-O2
MOLECULAR WEIGHT :
223.24
WISWESSER LINE NOTATION :
T56 BNVVJ BR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
425 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,858,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R23/24/25

[ Safety Phrases ]:
S27-S28-S36/37/39-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NL7984000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • isatin
  • Phenylboronic acid
  • 1-(2-(Phenylamino)phenyl)ethanone
  • phenylindole
  • Oxalyl chloride
  • Diphenylamine
  • (N,N-diphenylcarbamoyl) formyl chloride
  • 2-(2-bromophenyl)-N-phenylacetamide
  • N-Phenylamide of ethanedioic acid methyl ester
  • 2-trimethylsilylphenyl triflate

DownStream

  • Linopirdine(DuP-996)
  • 9-Acridinecarboxylic acid
  • Acridone
  • 1-Phenyloxindole
  • Methyl acridine-9-carboxylate
  • methyl 10-methylacridine-9-carboxylate; sulfooxymethane
  • 1-PHENYL-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
  • HT-2157
  • 2-Anilino phenylacetic Acid
  • 1,3,3-triphenylindol-2-one

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Unraveling the binding interaction and kinetics of a prospective anti-HIV drug with a model transport protein: results and challenges.

Phys. Chem. Chem. Phys. 15(4) , 1275-87, (2013)

The present contribution reports a detailed characterization of the binding interaction of a potential anticancer, anti-HIV drug 1-phenylisatin (1-PI) with a model transport protein Bovine Serum Album...

Fluorescence spectroscopic characterization of the interaction of human adult hemoglobin and two isatins, 1-methylisatin and 1-phenylisatin: a comparative study.

J. Phys. Chem. B 113(45) , 14904-13, (2009)

In this report, steady state and time-resolved fluorescence along with circular dichroism (CD) spectroscopic, FTIR, and anisotropy investigations were made to reveal the nature of the interactions bet...


More Articles

Related Compounds

  • 1-phenyl-3H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
  • 1-[2-(2-fluorobenzoyl)pyrrol-1-yl]propan-2-yl-dimethylazanium,chloride
  • 1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-bromo-ethanone
  • 1,4-BenzenediaMine, N,N,N',N'-tetrakis[4-[bis(2-Methylpropyl)aMino]phenyl]-
  • 1-[2-(2-methoxybenzoyl)pyrrol-1-yl]propan-2-yl-dimethylazanium,chloride
  • 1-(4-Amino-3,5-dichloro-phenyl)-2-tert-butylamino-ethanone Hydrochloride
  • 2-Methoxy-2-(pyrimidin-5-yl)ethan-1-amine
  • Cyclohexylmethanesulfinyl chloride
  • (1S)-5-chloro-6-fluoro-2,3-dihydro-1H-inden-1-amine
  • (S)-(6,6-Dimethylmorpholin-3-yl)methanol
  • 3-(Methoxymethyl)azetidine-3-carboxylic acid
  • 3-(1-Acetylazetidin-3-yl)-1,2-oxazole-5-carbaldehyde
  • 4-Methyloxolane-3-sulfonyl fluoride
  • 5-{7-Oxabicyclo[2.2.1]heptan-2-yl}-1,2-oxazole-4-carboxylic acid
  • 1-[(3As,7aR)-1,3,3a,4,7,7a-hexahydroisoindol-2-yl]prop-2-en-1-one
  • N-(1,1-Dioxidothietan-3-yl)-2-(methylamino)acetamide
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