2-Oxaspiro[4.5]decan-3-one

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Names

[ CAS No. ]:
7236-78-4

[ Name ]:
2-Oxaspiro[4.5]decan-3-one

[Synonym ]:
(1-Hydroxymethyl-cyclohexyl)-essigsaeure-lacton
3,3-pentamethylene-butyrolactone
Godecke
oxa-2 spiro<4,5>decanone-3
2-Oxa-spiro[4.5]decan-3-on
2-oxaspiro<4.5>decan-3-one
GO 177
(1-hydroxymethyl-cyclohexyl)-acetic acid-lactone

Chemical & Physical Properties

[ Density]:
1.07g/cm3

[ Boiling Point ]:
260.5ºC at 760 mmHg

[ Molecular Formula ]:
C9H14O2

[ Molecular Weight ]:
154.20600

[ Flash Point ]:
102.7ºC

[ Exact Mass ]:
154.09900

[ PSA ]:
26.30000

[ LogP ]:
1.88380

[ Index of Refraction ]:
1.488

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP3675000
CHEMICAL NAME :
2-Oxaspiro(4.5)decan-3-one
CAS REGISTRY NUMBER :
7236-78-4
BEILSTEIN REFERENCE NO. :
0119521
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H14-O2
MOLECULAR WEIGHT :
154.23
WISWESSER LINE NOTATION :
T5OV DXTJ D-& AL6XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,321,1972

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • SPIRO[3.5]NONAN-2-ONE
  • Methyl cyclohexanoate
  • 1,1-dichlorospiro[3,5]nonan-2-one
  • methyl 1-allylcyclohexanecarboxylate
  • Cyclohexane, methylene-
  • 1-(1-(2-propenyl)cyclohexyl)methanol
  • Formaldehyde
  • Ethyl oxo(2-oxocyclohexyl)acetate

DownStream

  • 1-(Carboxymethyl)cyclohexanecarboxylic acid

Related Compounds

  • 4-hydroxy-2-oxaspiro[4.5]decan-3-one
  • 4-(4-methylphenyl)-3-(piperidin-1-ylmethyl)-1-oxaspiro[4.5]decan-2-one,hydrochloride
  • 2-Oxaspiro[4.5]decan-8-one
  • 2-oxaspiro[4.5]decan-1-one
  • 2,8-Diazaspiro[4.5]decan-3-one dihydrochloride
  • 2,8-Diazaspiro[4.5]decan-3-one
  • [2-(tert-Butyldimethylsilanyloxy)ethyl]ethylamine
  • 1-(3-(3-fluorophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-morpholinoethanone
  • (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate
  • 1-((1-(3-Cyanopyridin-2-yl)piperidin-4-yl)methyl)-3-(2,6-difluorophenyl)urea
  • N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)-9H-xanthene-9-carboxamide
  • 3,4-dimethyl-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)benzenesulfonamide
  • 1-benzhydryl-3-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)urea
  • 3-(2-fluorophenyl)-N-((4-(phenylthio)tetrahydro-2H-pyran-4-yl)methyl)propanamide
  • (E)-3-(2-chlorophenyl)-1-(3-(5-(thiophen-3-yl)-1,3,4-oxadiazol-2-yl)piperidin-1-yl)prop-2-en-1-one
  • N,N-dimethyl-3-(5-(thiophen-3-yl)-1,3,4-oxadiazol-2-yl)piperidine-1-sulfonamide
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