Urea, (diphenylmethyl)- (8CI)(9CI)

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Names

[ CAS No. ]:
724-18-5

[ Name ]:
Urea, (diphenylmethyl)- (8CI)(9CI)

[Synonym ]:
Urea,1-diphenylmethyl
Benzhydryl-harnstoff

Chemical & Physical Properties

[ Density]:
1.156g/cm3

[ Boiling Point ]:
389.7ºC at 760 mmHg

[ Molecular Formula ]:
C14H14N2O

[ Molecular Weight ]:
226.27400

[ Flash Point ]:
189.5ºC

[ Exact Mass ]:
226.11100

[ PSA ]:
55.12000

[ LogP ]:
3.53550

[ Index of Refraction ]:
1.604

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YT2000000
CHEMICAL NAME :
Urea, 1-diphenylmethyl-
CAS REGISTRY NUMBER :
724-18-5
BEILSTEIN REFERENCE NO. :
2807619
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C14-H14-N2-O
MOLECULAR WEIGHT :
226.30
WISWESSER LINE NOTATION :
ZVM1R DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 39,355,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 39,355,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
45500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - proteinuria Endocrine - hyperglycemia
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 39,355,1976

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-Nitrocarbamide
  • diphenylmethylamine
  • Urea
  • Hydrazinecarboxamide,2-(diphenylmethylene)-
  • Benzhydrol
  • N-acetyl-N'-benzhydryl-urea
  • DIPHENYLKETENE
  • Potassium cyanate

DownStream

  • N-(benzhydrylcarbamoyl)quinoline-2-carboxamide

Related Compounds

  • Urea, 2-pyrimidinyl- (6CI,8CI,9CI)
  • Urea
  • Urea,(5-methyl-1,3,4-thiadiazol-2-yl)- (6CI,8CI,9CI)
  • Urea
  • distannyloxystannane
  • stannylsulfanylstannane
  • 3-(3,5-dimethyl-1,2-oxazol-4-yl)-N-{4-[5-(methoxymethyl)-4H-1,2,4-triazol-3-yl]phenyl}propanamide
  • 3-Amino-1-[2-(pyrrolidin-1-yl)ethyl]-1,2-dihydropyridin-2-one
  • 1-(3-Amino-4-methylpiperidin-1-yl)-2,2-dimethylpropan-1-one
  • 2-{2-Azabicyclo[2.2.1]heptan-2-yl}pyridine-3-carbaldehyde
  • [2-(1H-tetrazol-1-yl)phenyl]{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}methanone
  • Pyrimidine, 4-chloro-5-cyclopropyl-
  • N-[2-(5-chloro-1H-indol-3-yl)ethyl]-3-(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)propanamide
  • 2-[3-(Hydroxymethyl)pyrrolidin-1-yl]pyridine-3-carbaldehyde
  • 1-Cyclobutanecarbonyl-4-methylpiperidin-3-amine
  • 2-(2-Methylthiomorpholin-4-yl)pyridine-3-carbaldehyde
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