3-(2-Chloroactyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

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Names

[ CAS No. ]:
72578-71-3

[ Name ]:
3-(2-Chloroactyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

[Synonym ]:
(R)-2-Chloro-1-(2-((2-chloroethyl)amino)-2-oxido-1,3,2-oxazaphosphinan-3-yl)ethanone
3-chloroacetyl-2-(2-chloro-ethylamino)-[1,3,2]oxazaphosphinane (R)-2-oxide
IfofaMide acylation objects
IFOSFAMIDEACYLATE
3-(2-CHLOROACETYL)-2-[(2-CHLOROETHYL)AMINO]TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE-2-OXIDE
2-Chloro-1-{2-[(2-chloroethyl)amino]-2-oxido-1,3,2-oxazaphosphinan-3-yl}ethanone
Ethanone, 2-chloro-1-[2-[(2-chloroethyl)amino]dihydro-2-oxido-2H-1,3,2-oxazaphosphorin-3(4H)-yl]-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
355.0±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H13Cl2N2O3P

[ Molecular Weight ]:
275.069

[ Flash Point ]:
168.5±30.7 °C

[ Exact Mass ]:
274.004089

[ PSA ]:
68.45000

[ LogP ]:
1.73940

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.516

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R)-2-aziridin-1-yl-3-((R)-1-phenyl-ethyl)-[1,3,2]oxazaphosphinane 2-oxide
  • (2-chloro-ethyl)-[(S)-2-oxo-3-((R)-1-phenyl-ethyl)-2λ5-[1,3,2]oxazaphosphinan-2-yl]-amine
  • (2-chloro-ethyl)-[(R)-2-oxo-3-((R)-1-phenyl-ethyl)-2λ5-[1,3,2]oxazaphosphinan-2-yl]-amine
  • dechloroethylcyclophosphamide
  • Chloroacetyl chloride

DownStream

  • Ifosfamide

Related Compounds

  • (2S)-2-({1-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopropyl}formamido)hexanoic acid
  • 3-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methoxypropanamido]cyclopentane-1-carboxylic acid
  • 4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(3-methanesulfinylpropyl)carbamoyl]butanoic acid
  • (2R)-2-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]-4-(methylsulfanyl)butanoic acid
  • 2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5,5-dimethyl-N-propylhexanamido]acetic acid
  • 2-({1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbutanoyl]piperidin-4-yl}oxy)acetic acid
  • 4-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)acetamido}butanoic acid
  • 2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methanesulfonylbutanamido]ethoxy}acetic acid
  • 3-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]methyl}-5-methylhexanoic acid
  • (2S)-2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-(methoxymethyl)-N-methylbutanamido]propanoic acid
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