Dantrolene

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Names

[ CAS No. ]:
7261-97-4

[ Name ]:
Dantrolene

[Synonym ]:
Dantrium
1-[5-(4-nitro-phenyl)-furan-2-ylmethyleneamino]-imidazolidine-2,4-dione
1-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
Dantroleno [INN-Spanish]
Dantrolenum [INN-Latin]
UNII-F64QU97QCR
danthrolene
Dantrium Intravenous
Dantrolenum
1-[((5-(4-nitrophenyl)-2-furanyl)methylene)amino]-2,4-imidazolidinedione
Dantroleno

Chemical & Physical Properties

[ Density]:
1.57 g/cm3

[ Boiling Point ]:
175-177ºC

[ Melting Point ]:
279-280°C (lit.)

[ Molecular Formula ]:
C14H10N4O5

[ Molecular Weight ]:
314.25300

[ Exact Mass ]:
314.06500

[ PSA ]:
120.73000

[ LogP ]:
2.53040

[ Index of Refraction ]:
1.715

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MU3874000
CHEMICAL NAME :
Hydantoin, 1-((5-(p-nitrophenyl)furfurylidene)amino)-
CAS REGISTRY NUMBER :
7261-97-4
BEILSTEIN REFERENCE NO. :
0705189
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H10-N4-O5
MOLECULAR WEIGHT :
314.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,127,1978 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
9386 mg/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease
REFERENCE :
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 56,261,1980

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

  • dantrolene
  • DANTROLENE NA
  • Dantrolene-13C3
  • Dantrolene sodium
  • dantrolene sodium
  • Dantrolene Sodium
  • 2-[1-(4-Ethynylphenyl)cyclopropyl]acetic acid
  • 2,2,3-trifluoro-3-(1-methyl-1H-pyrazol-4-yl)propanoic acid
  • 1-(3-Methyl-5-(piperidin-4-yl)-4H-1,2,4-triazol-4-yl)propan-2-ol
  • 3-(4-benzyl-5-methyl-4H-1,2,4-triazol-3-yl)piperidine
  • 3-[5-methyl-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]piperidine
  • 4-[(3S)-3-aminobutyl]-N,N-dimethylaniline
  • (1S,2S)-2-[(prop-2-en-1-yl)amino]cyclobutan-1-ol
  • 3-(1-tert-butyl-1H-pyrazol-4-yl)-2,2,3-trifluoropropanoic acid
  • 3-(4-(sec-Butyl)-5-methyl-4H-1,2,4-triazol-3-yl)piperidine
  • 3-[3-methyl-5-(piperidin-3-yl)-4H-1,2,4-triazol-4-yl]propan-1-ol
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