Piritrexim

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Names

[ CAS No. ]:
72732-56-0

[ Name ]:
Piritrexim

[Synonym ]:
6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine
Piritrexime [French]
BW-301U
2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d ]pyrimidine
2,4-diamino-6-(2,5-dimethoxybenzyl)-2-methylpyrido[2,3-d]pyrimidine
Piritrexim
Piritrexima [Spanish]
Piritreximum [Latin]

Chemical & Physical Properties

[ Density]:
1.294g/cm3

[ Boiling Point ]:
603.315ºC at 760 mmHg

[ Molecular Formula ]:
C17H19N5O2

[ Molecular Weight ]:
325.36500

[ Flash Point ]:
318.674ºC

[ Exact Mass ]:
325.15400

[ PSA ]:
109.17000

[ LogP ]:
3.26800

[ Index of Refraction ]:
1.674

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1155860
CHEMICAL NAME :
Pyrido(2,3-d)pyrimidine-2,4-diamine, 6-((2,5-dimethoxyphenyl)methyl)-5-methyl-
CAS REGISTRY NUMBER :
72732-56-0
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C17-H19-N5-O2
MOLECULAR WEIGHT :
325.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1168 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
leu 10
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 65,503,1992

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloro-pyrido[2,3-d]pyrimidine
  • 2,5-Dimethoxybenzaldehyde
  • ethyl α-(2,5-dimethoxybenzylidene)acetoacetate
  • ethyl α-acetyl-β-(2,5-dimethoxyphenyl)propionate
  • 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d ]pyrimidine
  • 2-amino-3-cyano-4-methyl-5-(2,5-dimethoxybenzyl)pyridine
  • 2-amino-3-cyano-4-methylpyridine
  • 2-(4,4-dimethoxybutan-2-ylidene)propanedinitrile
  • 2-Amino-5-bromo-4-methylnicotinonitrile

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • PIRITREXIM ISETHIONATE
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 6-Amino-5-(difluoromethyl)pyridine-2,4-diol
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 1-(Piperidin-3-yl)but-3-yn-1-one
  • N-(4,4-difluorocyclohexyl)-3-methoxypropanamide
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde