Tolperisone

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Names

[ CAS No. ]:
728-88-1

[ Name ]:
Tolperisone

[Synonym ]:
tolperisone
Besnoline (free base)
EINECS 211-976-4
Roystajin (free base)
Mydetone
(RS)-tolperisone
Mideton
Mydocalm
Mydeton
Atmosgen (free base)
MFCD00242995
2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone
2-methyl-3-piperidin-1-yl-1-p-tolyl-propan-1-one
Menopatol
2,4'-dimethyl-3-piperidinopropiophenone

Chemical & Physical Properties

[ Density]:
1.004g/cm3

[ Boiling Point ]:
373.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₃NO

[ Molecular Weight ]:
245.36000

[ Flash Point ]:
134.4ºC

[ Exact Mass ]:
245.17800

[ PSA ]:
20.31000

[ LogP ]:
3.23760

[ Index of Refraction ]:
1.526

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UH1575000

CHEMICAL NAME :: Propiophenone, 2,4'-dimethyl-3-piperidino-

CAS REGISTRY NUMBER :: 728-88-1

BEILSTEIN REFERENCE NO. :: 1285666

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C16-H23-N-O

MOLECULAR WEIGHT :: 245.40

WISWESSER LINE NOTATION :: T6NTJ A1Y1&VR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1450 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 645 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Behavioral - rigidity (including catalepsy)

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 34,1634,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,257,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4'-Methylacetophenone
Piperidine
4'-Methyl-3-(1-piperidyl)propiophenone hydrochloride

DownStream

Related Compounds

tolperisone
l-Tolperisone
d-Tolperisone
Tolperisone-d10
Tolperisone HCl
R (-) Tolperisone-d10
tert-Butyl 4-oxooctahydropyrido[3,4-d]pyrimidine-7(1H)-carboxylate
4-(tert-Butyl)-2-formylbenzoic acid
(Z)-2-((3R,5S)-3,5-Bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethan-1-ol
tert-Butyl (S)-3-fluoro-3-((S)-1-hydroxyethyl)pyrrolidine-1-carboxylate
(R,E)-Trimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-2-yl)oxy)silane
tert-Butyl (tert-butoxycarbonyl)(2-chloro-4-methoxypyrimidin-5-yl)carbamate
rel-Isopropyl (1R,3R)-3-((2-(acetoxymethyl)-6-bromopyridin-3-yl)oxy)cyclohexane-1-carboxylate
3-Allyl-2-chloro-6,8-diiodoquinazolin-4(3H)-one
(1R,2S)-2-Amino-4-methylenecyclopentane-1-carboxylic acid hydrochloride
tert-Butyl 6-bromo-5-chloronicotinate

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