Dapiprazole

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Names

[ Name ]:
Dapiprazole

[Synonym ]:
Rev-Eyes
1,2,4-Triazolo[4,3-a]pyridine, 5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-
3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine
5,6,7,8-Tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine
Dapiprazole
Dapiprazol [German]
Dapirazol
Glamidolo
3-{2-[4-(2-Methylphenyl)piperazin-1-yl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
3-[2-(4-o-tolyl-piperazin-1-yl)-ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine
3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
5,6,7,8-Tetrahydro-3-[2-(4-o-tolyl-1-piperazinyl)ethyl]-s-triazolo[4,3-a]pyridine
5,6,7,8-tetrahydro-3-[2-(4-o-tolyl-1-piperazin)ethyl]-1,2,4-triazolo[4,3-a]pyridine
Reversil
Dapiprazole [INN]
Dapiprazol
dapiprazolum
Dapirazolum

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
538.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₇N₅

[ Molecular Weight ]:
325.451

[ Flash Point ]:
279.7±32.9 °C

[ Exact Mass ]:
325.226654

[ PSA ]:
37.19000

[ LogP ]:
2.44

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.658

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ5625000

CHEMICAL NAME :: s-Triazolo(4,3-a)pyridine, 5,6,7,8-tetrahydro-3-(2-(4-(o-tolyl)-1-piperazinyl)et hyl)-, hydrochloride

CAS REGISTRY NUMBER :: 72822-12-9

LAST UPDATED :: 199009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H27-N5.Cl-H

MOLECULAR WEIGHT :: 361.97

WISWESSER LINE NOTATION :: T56 AN CNN&TJ B2- AT6N DNTJ DR B1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,668,1982