Guanine

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Names

[ CAS No. ]:
73-40-5

[ Name ]:
Guanine

[Synonym ]:
MFCD00071533
dewpearl
Guanin
2-amino-Hypoxanthine
9H-purin-6-ol, 2-amino-
2-amino-3,7-dihydro-6H-purin-6-one
7H-Purin-6-ol, 2-amino-
Guanine
2-amino-9H-purin-6-ol
Guanie
2-amino-6-oxypurine
Gua
guamine
EINECS 200-799-8
2-amino-1,7-dihydro-6H-purin-6-one
2-amino-1,9-dihydro-6H-purin-6-one
quanine
2-amino-6-hydroxypurine
Ganciclovir Impurity 6

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Boiling Point ]:
561.5±42.0 °C at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C5H5N5O

[ Molecular Weight ]:
151.126

[ Flash Point ]:
293.4±27.9 °C

[ Exact Mass ]:
151.049408

[ PSA ]:
100.45000

[ LogP ]:
-2.03

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
2.047

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
practically insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF8260000
CHEMICAL NAME :
Guanine
CAS REGISTRY NUMBER :
73-40-5
LAST UPDATED :
199709
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C5-H5-N5-O
MOLECULAR WEIGHT :
151.15
WISWESSER LINE NOTATION :
T56 BM DN FVM INJ HZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - ovarian tumors

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 19,40,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2576 No. of Facilities: 1778 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 4133 (estimated) No. of Female Employees: 3339 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MF8260000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Acyclovir
  • 9H-Purin-2-amine,6-[(phenylmethyl)thio]-
  • 2,6-diamino-5-nitrosopyrimidin-4-ol
  • platinum
  • N,9-Diacetylguanine
  • Guanosine
  • 2H-1,2,4-triazole-3-carbonitrile
  • 2'-Deoxyguanosine
  • 2,6-Diaminopurine

DownStream

  • 2'-Monodehydroxy-2'-chloro Ganciclovir
  • Penciclovir
  • 8-bromoguanine
  • Cyanogen chloride
  • N'-(6-chloro-7H-purin-2-yl)-N,N-dimethylmethanimidamide
  • N-BENZYL-2-CHLORO-9H-PURIN-6-AMINE
  • Benzoic acid,4-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-
  • 9-(2-Bromoethyl)-6-chloro-9H-purin-2-amine
  • Acyclovir
  • 9-[[2-chloroethoxy]methyl]guanine

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Related Compounds

  • guanine
  • 8-guanine
  • CE-Guanine
  • Epiguanine
  • Guanine HCl
  • Guanine-13C
  • 4-{[(1,3-Oxazol-4-yl)methoxy]methyl}piperidine
  • (1-Benzylpyrrol-2-yl)oxy-tert-butyl-dimethylsilane
  • 5-Bromo-1-isobutyl-1H-indole-2-carboxylic acid ethyl ester
  • 5-Bromo-1-(2-methoxyethyl)-1H-indole-2-carboxylic acid
  • (3-Bromophenyl)(3-(fluoromethyl)azetidin-1-yl)methanone
  • N-(4,4-difluorocyclohexyl)-1-ethyl-1H-pyrazole-3-carboxamide
  • 1-(1-((5-Ethylthiophen-2-yl)sulfonyl)azetidin-3-yl)piperidine-4-carboxamide
  • 1-(1-((2-Bromophenyl)sulfonyl)azetidin-3-yl)piperidine-4-carboxamide
  • (3-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)azetidin-1-yl)(5-methylisoxazol-3-yl)methanone
  • (3-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)azetidin-1-yl)(2,5-dimethylfuran-3-yl)methanone
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