bendroflumethiazide

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Names

[ CAS No. ]:
73-48-3

[ Name ]:
bendroflumethiazide

[Synonym ]:
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide
Pluryl
benzoflumethiazide
3-Benzyl-6-(trifluorométhyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxyde
Bendrofluazide
3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide
Naturetin
3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
3-Benzyl-3,4-dihydro-7-sulfamyl-6-trifluoromethyl-1,2,4-benzothiadiazine 1,1-Dioxide
3-Benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Benzydroflumethiazide
Centyl
Benzylrodiuran
Berkozide
bendroflumethiazide
bendroflumethazide
Neo-naclex
Naturine
3-(Phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
bendroflumetazide
Aprinox
T66 BSWM EM DHJ D1R& HXFFF ISZW
Salures

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
602.1±65.0 °C at 760 mmHg

[ Melting Point ]:
205-207ºC

[ Molecular Formula ]:
C₁₅H₁₄F₃N₃O₄S₂

[ Molecular Weight ]:
421.415

[ Flash Point ]:
318.0±34.3 °C

[ Exact Mass ]:
421.037781

[ PSA ]:
135.12000

[ LogP ]:
2.07

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.584

[ Water Solubility ]:
Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent).

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK8225000

CHEMICAL NAME :: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

CAS REGISTRY NUMBER :: 73-48-3

BEILSTEIN REFERENCE NO. :: 0373316

LAST UPDATED :: 199806

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H14-F3-N3-O4-S2

MOLECULAR WEIGHT :: 421.44

WISWESSER LINE NOTATION :: T66 BSWM EM DHJ D1R& HXFFF ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 300 ug/kg/3D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in sodium

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22750 mg/kg/26W-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - changes in calcium Nutritional and Gross Metabolic - changes in metals, not otherwise specified

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3640 mg/kg/26W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Nutritional and Gross Metabolic - changes in potassium

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 200 mg/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
DK8225000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,4-disulfamyl-5-trifluoromethylaniline
Phenylacetaldehyde
(2,2-Dimethoxyethyl)benzene

DownStream

(R)-Bendroflumethiazide
(S)-Bendroflumethiazide
2,4-disulfamyl-5-trifluoromethylaniline

Articles

Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. I: Investigation of mobile phase and MS conditions.

Anal. Chim. Acta 853 , 637-46, (2014)

The conditions for the analysis of selected doping substances by UHPSFC-MS/MS were optimized to ensure suitable peak shapes and maximized MS responses. A representative mixture of 31 acidic and basic ...

Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. II: Analysis of biological samples.

Anal. Chim. Acta 853 , 647-59, (2014)

The potential and applicability of UHPSFC-MS/MS for anti-doping screening in urine samples were tested for the first time. For this purpose, a group of 110 doping agents with diverse physicochemical p...

Binding of diuretic antihypertensive bendroflumethiazide to human serum albumin studied by ¹⁹F nuclear magnetic resonance method.

Eur. J. Pharm. Sci. 45(1-2) , 195-200, (2012)

Simultaneous specific and nonspecific binding of bendroflumethiazide (BFZ) to human serum albumin (HSA) and concentration profile of BFZ in HSA buffer (pH 7.40) solution were investigated by ¹⁹F nucle...

(R)-Bendroflumethiazide
(S)-Bendroflumethiazide
rac-Bendroflumethiazide-d5
bendroflumethiazide impurity A
5-Bromo-2-(2,6-dichlorophenyl)oxazole-4-carbonitrile
3-Fluoro-4,4-dimethylpyrrolidin-2-one
tert-butyl N-[2-amino-1-(thiophen-2-yl)ethyl]carbamate
3-(1-(4-fluorobenzyl)-1H-pyrrol-3-yl)-4-methylpyridine
2-(2-Phenoxyethyl)morpholine
tert-butyl N-[2-amino-1-(4-hydroxy-3-methoxyphenyl)ethyl]carbamate
2-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)ethan-1-ol
(R)-3,3,6,6-tetramethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one
2-[(4-Methylpiperazin-1-yl)methyl]-1,3-thiazole-4-carbaldehyde
3-(4-Bromo-3,5-dimethylphenyl)propanenitrile

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