2-Amino-5-methylthiazole

Names

[ Name ]:
2-Amino-5-methylthiazole

[Synonym ]:
Thiazole, 2-amino-5-methyl-
2-Amino-5-methylthiazole
2-Thiazolamine, 5-methyl-
MFCD00078317
5-Methyl-1,3-thiazol-2-amine
5-Methyl-2-thiazolamine
T5N CSJ BZ D1
EINECS 423-800-5

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
232.5±9.0 °C at 760 mmHg

[ Melting Point ]:
93-98 °C(lit.)

[ Molecular Formula ]:
C₄H₆N₂S

[ Molecular Weight ]:
114.17

[ Flash Point ]:
94.4±18.7 °C

[ Exact Mass ]:
114.025169

[ PSA ]:
67.15000

[ LogP ]:
0.84

[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.618

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R48/22;R50/53

[ Safety Phrases ]:
S60-S61-S29-S26

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Propionaldehyde
Potassium thiocyanate
Chloroacetone
CHLOROPROPANAL
1-Propanol
2-Bromopriopionaldehyde diethyl acetyl
2-Bromopropanal

DownStream

2-Chloro-5-methylthiazole
5-Methylthiazole
2-Bromo-5-methylthiazole
Meloxicam
N-[(2E)-3,5-Dimethyl-1,3-thiazol-2(3H)-ylidene]-4-hydroxy-2-methy l-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
5-methylthiazole-2-carbaldehyde
Acetamide, 2,2,2-trifluoro-N-(5-methyl-2-thiazolyl)- (9CI)
N-(5-methyl-1,3-thiazol-2-yl)acetamide

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.

Bioorg. Med. Chem. 16 , 6193-206, (2008)

Selective inhibitors of neuronal nitric oxide synthase (nNOS) were shown to protect brain and may be useful in the treatment of neurodegenerative diseases. In this context, our purpose has been to des...

Copper(II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazole: synthesis, characterization, antiproliferative and antibacterial studies. Crystal structure of CudienOOCl2.

J. Inorg. Biochem. 98(8) , 1271-83, (2004)

A new series of coordination compounds of the starting materials [Cu(dienX(2)Y(2))] and their adducts [Cu(dienXXY(2))(2a-5mt)] (where dien=diethylenetriamine, dienXX=Schiff bases of diethylenetriamine...

Antiproliferative activity of mixed-ligand dien-Cu(II) complexes with thiazole, thiazoline and imidazole derivatives.

J. Inorg. Biochem. 88(1) , 25-36, (2002)

The reaction of [Cu(dien)NO(3)]NO(3) with 2-amino-5-methylthiazole (2A5MT), 2-amino-2-thiazoline (2A-2Tzn), imidazole (im), N,N'-thiocarbonyldiimidazole (Tcdim), 2-aminothiazole (2AT) and 2-ethylimida...

2-amino-5-methylthiazole
2-Amino-5-methylthiazole-4-carboxamide
2-Amino-5-methylthiazole-4-carbaldehyde
2-Amino-5-methylthiazole-4-carbonitrile
2-Amino-5-methylthiazole-4-carbohydrazide
2-Amino-5-methylthiazole-4-carboxylic acid
6-Bromo-2-iodoquinoline
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-(4-((2,6-dimethylpyrimidin-4-yl)oxy)piperidin-1-yl)-2-(1H-pyrazol-1-yl)ethanone
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
6-Bromo-4-(2-methoxyethoxy)-1H-indazole
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde