(2S)-2-Amino-4-(Methylsulfonyl)-Butanoic Acid

Suppliers

Names

[ Name ]:
(2S)-2-Amino-4-(Methylsulfonyl)-Butanoic Acid

[Synonym ]:
methionine sulfone zwitterion
EINECS 230-774-7
MFCD00066020
2-Amino-4-(methylsulfonyl)butanoic acid
L-METHIONINE SULFONE
Methionine sulfone
Butanoic acid, 2-amino-4-(methylsulfonyl)-, (2S)-
(2S)-2-Amino-4-(methylsulfonyl)butanoic acid
Butanoic acid, 2-amino-4-(methylsulfonyl)-
UNII:5503K54L0R

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
450.5±40.0 °C at 760 mmHg

[ Melting Point ]:
~275 °C (dec.)

[ Molecular Formula ]:
C₅H₁₁NO₄S

[ Molecular Weight ]:
181.21

[ Flash Point ]:
226.3±27.3 °C

[ Exact Mass ]:
181.040878

[ PSA ]:
105.84000

[ LogP ]:
-1.27

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.512

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

L-Methionine
H-Met(O)-OH
Formic Acid
trans-5-chloro-6-hydroperoxy-5,6-dihydrothymine
dl-methionine sulfone
DL-Methionine
acetylamino-(2-methanesulfonyl-ethyl)-malonic acid diethyl ester
Sulfuric acid
L-Met(S)SO

DownStream

Articles

In Salmonella enterica, the Gcn5-related acetyltransferase MddA (formerly YncA) acetylates methionine sulfoximine and methionine sulfone, blocking their toxic effects.

J. Bacteriol. 197(2) , 314-25, (2015)

Protein and small-molecule acylation reactions are widespread in nature. Many of the enzymes catalyzing acylation reactions belong to the Gcn5-related N-acetyltransferase (GNAT; PF00583) family, named...

Copper(II) complexes of neurokinin A with point mutation (S5A) and products of copper-catalyzed oxidation; role of serine residue in peptides containing neurokinin A sequence.

J. Inorg. Biochem. 121 , 1-9, (2013)

A potentiometric, spectroscopic (UV-visible, CD and EPR) and electrospray ionization mass spectrometric (ESI-MS) study of Cu(II) binding to the neurokinin A with point mutation (S5A) (ANKA), His-Lys-T...

Metabolomics study of hepatocellular carcinoma: discovery and validation of serum potential biomarkers by using capillary electrophoresis-mass spectrometry.

J. Proteome Res. 13(7) , 3420-31, (2014)

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. The lack of effective screening methods for early diagnosis has been a longstanding bottleneck to improve the survival rate. In t...

Boc-Met(O2)-OH
methionine sulfone
(2S)-2-AMINO-4-FLUORO-BUTANOIC ACID
(2S)-2-amino-4-(propylsulfonimidoyl)butanoic acid
(2S)-2-amino-4-(ethylselanyl)butanoic acid
(2S)-2-amino-4-(methylsulfonimidoyl)butanoic acid,phosphoric acid
4-(4-chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(1H-pyrrol-1-yl)thiophene-2-carboxamide
2,3-Dimethylbutane-1-sulfonamide
Ethyl 4-[[3-(aminocarbonyl)phenyl]methyl]-1-(cyclohexylmethyl)-4-piperidinecarboxylate
1-Amino-3-(naphthalen-2-yl)propan-2-ol
2-(4-methylphenyl)-4-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]phthalazin-1(2H)-one
1-(Trifluoromethyl)cyclopentane-1-carbonitrile
N-[5-(6-chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide
2,2,4-Trimethyl-6-(trifluoromethoxy)-1H-quinoline
2-(3-chlorophenyl)-4-[3-(3,4-dimethylphenyl)-1,2,4-oxadiazol-5-yl]phthalazin-1(2H)-one
2-(3,4-dimethylphenyl)-4-[3-(4-ethylphenyl)-1,2,4-oxadiazol-5-yl]phthalazin-1(2H)-one

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