Florfenicol

Suppliers

Names

[ CAS No. ]:
73231-34-2

[ Name ]:
Florfenicol

[Synonym ]:
Florfenicol
2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methanesulfonyl)phenyl]ethyl]acetamide
NUFLOR
2,2-dichloro-N-[(1S
AQUAFEN
Fluorothiamphenicol
2,2-DIBROMODECAFLUOROPENTANE
2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
Florfeniol
Aquaflor
MFCD00864834
EINECS 642-986-0

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
617.5±55.0 °C at 760 mmHg

[ Melting Point ]:
153 °C

[ Molecular Formula ]:
C12H14Cl2FNO4S

[ Molecular Weight ]:
358.213

[ Flash Point ]:
327.3±31.5 °C

[ Exact Mass ]:
357.000458

[ PSA ]:
91.85000

[ LogP ]:
-0.12

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.548

[ Storage condition ]:
0-6°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB6034000
CHEMICAL NAME :
Benzenesulfonic acid, 4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl )-, methyl ester, (R-(R*,S*))-
CAS REGISTRY NUMBER :
73231-34-2
LAST UPDATED :
198806
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H11-Cl2-F-N2-O4
MOLECULAR WEIGHT :
325.14
WISWESSER LINE NOTATION :
WNR DYQY1FMVYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,172,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Synthetic Route

Precursor & DownStream

Precursor

  • Ethyl dichloroacetate
  • Methyldichloroacetate
  • Florfenicol amine
  • Thiamphenicol Impurity 1
  • Dichloroacetyl chloride
  • 3-(dichloroacetyl)-4(S)-(fluoromethyl)-2,2-dimethyl-5(R)-[4-(methylsulfonyl)phenyl]oxazolidine
  • 3-(dichloroacetyl)-4(R)-(hydroxymethyl)-5(R)-[4-(methylsulfonyl)phenyl]-2-oxazolidinone
  • 3-(dichloroacetyl)-4(S)-(fluoromethyl)-5(R)-[4-(methylsulfonyl)phenyl]-2-oxazolidinone

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Multiresidue method for the determination of pharmacologically active substances in egg and honey using a continuous solid-phase extraction system and gas chromatography-mass spectrometry.

Food Chem. 178 , 63-9, (2015)

A sensitive, selective, efficient gas chromatography-mass spectrometry method for the simultaneous determination of 22 pharmacologically active substances (antibacterials, nonsteroidal antiinflammator...

Development and validation of determinative and confirmatory LC-MS/MS methodologies for total florfenicol and tulathromycin residues in bovine, equine and porcine kidney, liver and muscle tissues.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 1-9, (2015)

Separate methods for the quantitation and confirmation of regulatory relevant residue concentrations of total florfenicol and tulathromycin residues in multiple tissue matrices were developed and vali...

Preparation and evaluation of poly(alkyl methacrylate-co-methacrylic acid-co-ethylene dimethacrylate) monolithic columns for separating polar small molecules by capillary liquid chromatography.

Anal. Chim. Acta 871 , 57-65, (2015)

In this study, methacrylic acid (MAA) was incorporated with alkyl methacrylates to increase the hydrophilicity of the synthesized ethylene dimethacrylate-based (EDMA-based) monoliths for separating po...


More Articles


Related Compounds

  • Florfenicol
  • Florfenicol-d3
  • Florfenicol amine
  • ent-Florfenicol-d3
  • Florfenicol-d3 AMine
  • Deschloro Florfenicol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • rac-tert-butyl (3R,4S)-3-hydroxy-4-(4-hydroxyphenyl)pyrrolidine-1-carboxylate
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide