Florfenicol

Suppliers

Names

[ CAS No. ]:
73231-34-2

[ Name ]:
Florfenicol

[Synonym ]:
Florfenicol
2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methanesulfonyl)phenyl]ethyl]acetamide
NUFLOR
2,2-dichloro-N-[(1S
AQUAFEN
Fluorothiamphenicol
2,2-DIBROMODECAFLUOROPENTANE
2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
Florfeniol
Aquaflor
MFCD00864834
EINECS 642-986-0

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
617.5±55.0 °C at 760 mmHg

[ Melting Point ]:
153 °C

[ Molecular Formula ]:
C12H14Cl2FNO4S

[ Molecular Weight ]:
358.213

[ Flash Point ]:
327.3±31.5 °C

[ Exact Mass ]:
357.000458

[ PSA ]:
91.85000

[ LogP ]:
-0.12

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.548

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB6034000
CHEMICAL NAME :
Benzenesulfonic acid, 4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl )-, methyl ester, (R-(R*,S*))-
CAS REGISTRY NUMBER :
73231-34-2
LAST UPDATED :
198806
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H11-Cl2-F-N2-O4
MOLECULAR WEIGHT :
325.14
WISWESSER LINE NOTATION :
WNR DYQY1FMVYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,172,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl dichloroacetate
  • Methyldichloroacetate
  • Florfenicol amine
  • Thiamphenicol Impurity 1
  • Dichloroacetyl chloride
  • 3-(dichloroacetyl)-4(S)-(fluoromethyl)-2,2-dimethyl-5(R)-[4-(methylsulfonyl)phenyl]oxazolidine
  • 3-(dichloroacetyl)-4(R)-(hydroxymethyl)-5(R)-[4-(methylsulfonyl)phenyl]-2-oxazolidinone
  • 3-(dichloroacetyl)-4(S)-(fluoromethyl)-5(R)-[4-(methylsulfonyl)phenyl]-2-oxazolidinone

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

  • Florfenicol
  • Methyl 2-phenyl-2-piperidin-4-ylacetate;hydrochloride
  • 3-Cyclohexyl-N-methylaniline;hydrochloride
  • 5-Cyano-4-methylisoxazole-3-carboxylic acid
  • Methyl 5-cyano-6-formyl-3,4-dimethylpicolinate
  • (2R)-N-Boc-2-ethynylazetidine
  • Methyl (3S,4S)-4-cyclopentylpyrrolidine-3-carboxylate;hydrochloride
  • rac-tert-butyl(3aR,6aS)-2,2-dioxo-hexahydro-1H-2lambda6-thieno[3,4-c]pyrrole-3a-carboxylatehydrochloride,cis
  • Ethyl (3aR,6aS)-2,2-dioxo-1,3,4,5,6,6a-hexahydrothieno[3,4-c]pyrrole-3a-carboxylate;hydrochloride
  • 3-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide
  • 3-Bromo-5-chloro-4-cyclopropylphenylboronic Acid Pinacol Ester
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