Methylnaltrexone (Bromide)

Suppliers

Names

[ CAS No. ]:
73232-52-7

[ Name ]:
Methylnaltrexone (Bromide)

[Synonym ]:
[14C]-N-Methylnaltrexone bromide
MNTX bromide
Naltrexone methobromide
(-)-naltrexone methyl bromide
Relistor
Methylnaltrexone (Bromide)
MRZ-2663BR
MOA-728
Relistor (TN)
MNTX

Chemical & Physical Properties

[ Melting Point ]:
237-239ºC

[ Molecular Formula ]:
C21H26BrNO4

[ Molecular Weight ]:
436.33900

[ Exact Mass ]:
435.10500

[ PSA ]:
69.59000

[ LogP ]:
3.02510

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H400

[ Precautionary Statements ]:
P273-P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ RTECS ]:
QD0188550

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methyl bromide
  • naltrexone
  • N-methylnaltrexone zwitterion
  • (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-9-((ethoxycarbonyl)oxy)-4a-hydroxy-3-methyl-7-oxo-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium methyl sulfate

DownStream

Articles

Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysis.

Am. J. Gastroenterol. 108(10) , 1566-74; quiz 1575, (2013)

There has been no definitive synthesis of the evidence for any benefit of available pharmacological therapies in opioid-induced constipation (OIC). We conducted a systematic review and meta-analysis t...

[Opiate induced constipation--mechanisms, relevance and treatment].

Dtsch. Med. Wochenschr. 138(43) , 2207-11, (2013)

Effects of remifentanil on the esophagogastric junction and swallowing.

Acta Anaesthesiol. Scand. 57(8) , 1002-9, (2013)

A recent study demonstrated that reflux is associated with impaired pressure augmentation in the esophagogastric junction (EGJ), caused by diaphragmal contractions during inspiration. It is unknown wh...


More Articles

Related Compounds

  • Methylnaltrexone (Bromide)
  • N-Methyl 7,8-didehydronaltrexone Bromide
  • Methylnaltrexone D3 Bromide
  • dichloroacetyl bromide
  • Decamethonium Bromide
  • isobornyl bromide
  • 1-Amino-4-(4-bromophenyl)butan-2-one
  • 2-[4-(2,2,2-Trifluoroacetamido)cyclohexyl]acetic acid
  • 1-Methyl-4-(m-tolyl)piperidine-4-carbonitrile
  • 4-(2-Chloro-6-fluorophenyl)-1-methyl-4-piperidinecarbonitrile
  • 4-(3,4-Dimethoxy-phenyl)-1-methyl-piperidine-4-carbonitrile
  • N,Na(2)-2,6-Pyridinediylbis[4-nitrobenzenesulfonamide]
  • 4-(Pent-3-yn-1-yl)phenol
  • 1-(1,1-Dimethylethyl) 4-ethyl 4-(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)-1,4-piperidinedicarboxylate
  • (2E)-3-(3-Chloro-2-methylphenyl)prop-2-enoic acid
  • 4,5-Diethyl-1H-imidazole-2-carbaldehyde
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