Methylnaltrexone (Bromide)

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Names

[ CAS No. ]:
73232-52-7

[ Name ]:
Methylnaltrexone (Bromide)

[Synonym ]:
[14C]-N-Methylnaltrexone bromide
MNTX bromide
Naltrexone methobromide
(-)-naltrexone methyl bromide
Relistor
Methylnaltrexone (Bromide)
MRZ-2663BR
MOA-728
Relistor (TN)
MNTX

Chemical & Physical Properties

[ Melting Point ]:
237-239ºC

[ Molecular Formula ]:
C21H26BrNO4

[ Molecular Weight ]:
436.33900

[ Exact Mass ]:
435.10500

[ PSA ]:
69.59000

[ LogP ]:
3.02510

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H400

[ Precautionary Statements ]:
P273-P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ RTECS ]:
QD0188550

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methyl bromide
  • naltrexone
  • N-methylnaltrexone zwitterion
  • (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-9-((ethoxycarbonyl)oxy)-4a-hydroxy-3-methyl-7-oxo-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium methyl sulfate

DownStream

Articles

Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysis.

Am. J. Gastroenterol. 108(10) , 1566-74; quiz 1575, (2013)

There has been no definitive synthesis of the evidence for any benefit of available pharmacological therapies in opioid-induced constipation (OIC). We conducted a systematic review and meta-analysis t...

[Opiate induced constipation--mechanisms, relevance and treatment].

Dtsch. Med. Wochenschr. 138(43) , 2207-11, (2013)

Effects of remifentanil on the esophagogastric junction and swallowing.

Acta Anaesthesiol. Scand. 57(8) , 1002-9, (2013)

A recent study demonstrated that reflux is associated with impaired pressure augmentation in the esophagogastric junction (EGJ), caused by diaphragmal contractions during inspiration. It is unknown wh...


More Articles

Related Compounds

  • Methylnaltrexone (Bromide)
  • N-Methyl 7,8-didehydronaltrexone Bromide
  • Methylnaltrexone D3 Bromide
  • dichloroacetyl bromide
  • Decamethonium Bromide
  • isobornyl bromide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 5-(3-Methylideneazetidin-1-yl)pyridine-2-carbaldehyde
  • 1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbutanoyl]-5-hydroxypiperidine-3-carboxylic acid
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine