Geldanamycin,18,21-didehydro-6,17-didemethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-6-methyl-11-O-methyl-,(6S,15R)-

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Names

[ CAS No. ]:
73341-73-8

[ Name ]:
Geldanamycin,18,21-didehydro-6,17-didemethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-6-methyl-11-O-methyl-,(6S,15R)-

[Synonym ]:
macbecin II

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
698.9ºC at 760 mmHg

[ Molecular Formula ]:
C30H44N2O8

[ Molecular Weight ]:
560.67900

[ Flash Point ]:
376.5ºC

[ Exact Mass ]:
560.31000

[ PSA ]:
149.57000

[ LogP ]:
5.81680

[ Index of Refraction ]:
1.565

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OL9056000
CHEMICAL NAME :
Macbecin II
CAS REGISTRY NUMBER :
73341-73-8
LAST UPDATED :
198509
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C30-H44-N2-O8.H2-O
MOLECULAR WEIGHT :
578.78
WISWESSER LINE NOTATION :
T6-19- A GMV IU KU OU&TJ AQ DQ I1 M1 NOVZ O1 Q1 RO1 SO1 U1 VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
10 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,321,1983

Precursor & DownStream

Precursor

DownStream

  • Ethanoic anhydride

Related Compounds

  • 2-Amino-1-(2-methyl-2h-1,2,3,4-tetrazol-5-yl)ethan-1-one
  • Tert-butyl 2-(5-bromo-6-cyanopyridin-3-ylamino)ethylcarbamate
  • 2-[5-(6-Amino-4-methylpyridin-2-yl)-1,3-thiazol-2-yl]propan-2-ol
  • 4-Methyl-6-(1-methylpyrazol-4-yl)pyridin-2-amine
  • 3-(1-Acetylpyrrolidin-3-yl)propanoic acid
  • 8-Oxa-4-azaspiro[2.6]nonan-5-one
  • 4-methyl-6-(2H-1,2,3-triazol-2-yl)pyridin-2-amine
  • 3-Azabicyclo[3.1.1]heptane-2-carboxylic acid
  • N-(6-Trifluroacetamidohexanoyl)-L-aspartic acid
  • 1-(3,3-difluoropropyl)-1H-pyrazole
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