Geldanamycin,18,21-didehydro-6,17-didemethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-6-methyl-11-O-methyl-,(6S,15R)-

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Names

[ CAS No. ]:
73341-73-8

[ Name ]:
Geldanamycin,18,21-didehydro-6,17-didemethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-6-methyl-11-O-methyl-,(6S,15R)-

[Synonym ]:
macbecin II

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
698.9ºC at 760 mmHg

[ Molecular Formula ]:
C30H44N2O8

[ Molecular Weight ]:
560.67900

[ Flash Point ]:
376.5ºC

[ Exact Mass ]:
560.31000

[ PSA ]:
149.57000

[ LogP ]:
5.81680

[ Index of Refraction ]:
1.565

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OL9056000
CHEMICAL NAME :
Macbecin II
CAS REGISTRY NUMBER :
73341-73-8
LAST UPDATED :
198509
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C30-H44-N2-O8.H2-O
MOLECULAR WEIGHT :
578.78
WISWESSER LINE NOTATION :
T6-19- A GMV IU KU OU&TJ AQ DQ I1 M1 NOVZ O1 Q1 RO1 SO1 U1 VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
10 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,321,1983

Precursor & DownStream

Precursor

DownStream

  • Ethanoic anhydride

Related Compounds

  • N-(2-phenoxyethyl)piperidin-4-amine dihydrochloride
  • 3-(2-ethyl-1H-imidazol-1-yl)piperidine dihydrochloride
  • 2-(Butan-2-yl)piperidine hydrochloride
  • (2,4,6-Tribromophenyl)hydrazine hydrochloride
  • 2-(2,3-Difluorophenoxy)-1-(piperazin-1-yl)propan-1-one hydrochloride
  • Phenyl (6-ethylpyridin-2-yl)carbamate
  • 2-[3-(Trifluoromethyl)phenyl]propan-1-amine hydrochloride
  • methyl[(2-phenyl-2H-1,2,3-triazol-4-yl)methyl]amine hydrochloride
  • [2-(4-Methoxyphenyl)ethyl]hydrazine dihydrochloride
  • 4-[4-(Difluoromethoxy)phenyl]oxan-4-amine hydrochloride
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