L-Glutamic acid, N-[N-[N-[N-[4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-.gamma.-gluta myl]-L-.gamma.-glutamyl]-L-.gamma.-glutamyl]-

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Names

[ CAS No. ]:
73610-81-8

[ Name ]:
L-Glutamic acid, N-[N-[N-[N-[4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-.gamma.-gluta myl]-L-.gamma.-glutamyl]-L-.gamma.-glutamyl]-

[Synonym ]:
methotrexate triglutamate
4-NH2-10-CH3-folyldiglutamate
MTX triglutamate
L-Glutamic acid,N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-g-glutamyl
4-NH2-10-CH3-folyltriglutamate
MTX diglutamate
methotrexate tetraglutamate
4-NH2-10-CH3-folyltetraglutamate
4-amino-4-deoxy-N10-methylpteroyltetraglutamate
4-Amino-4-deoxy-N10-methylpteroylglutamyl-g-glutamate
4-amino-10-methylpteroyldiglutamate
MTX tetraglutamate

Chemical & Physical Properties

[ Density]:
1.541g/cm3

[ Molecular Formula ]:
C35H43N11O14

[ Molecular Weight ]:
841.78100

[ Exact Mass ]:
841.29900

[ PSA ]:
409.74000

[ LogP ]:
1.04320

[ Index of Refraction ]:
1.669

Synthetic Route

Precursor & DownStream

Precursor

  • 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
  • (3S,8S,13S,18S)-1-(4-(methylamino)phenyl)-1,6,11,16-tetraoxo-2,7,12,17-tetraazaicosane-3,8,13,18,20-pentacarboxylic acid
  • Boc-L-glutamic acid 1-benzyl ester
  • pentabenzyl (3S,8S,13S,18S)-1-(4-(((benzyloxy)carbonyl)(methyl)amino)phenyl)-1,6,11,16-tetraoxo-2,7,12,17-tetraazaicosane-3,8,13,18,20-pentacarboxylate
  • tetrabenzyl (6S,11S,16S)-2,2-dimethyl-4,9,14-trioxo-3-oxa-5,10,15-triazaoctadecane-6,11,16,18-tetracarboxylate
  • N-[N-(L-γ-glutamyl)-L-γ-glutamyl]-L-glutamic acid tetrabenzyl ester hydrochloride
  • 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride
  • H-Glu-OtBu
  • 4-Amino-4-deoxy-10-methylpteroic acid

DownStream