4-[1-Hydroxy-2-(isopropylamino)ethyl]phenol

Names

[ CAS No. ]:
7376-66-1

[ Name ]:
4-[1-Hydroxy-2-(isopropylamino)ethyl]phenol

[Synonym ]:
para-phenylethynylphenyl isocyanate
Paraproterenol

Chemical & Physical Properties

[ Density]:
1.099 g/cm3

[ Boiling Point ]:
355.9ºC at 760mmHg

[ Molecular Formula ]:
C11H17NO2

[ Molecular Weight ]:
195.25800

[ Flash Point ]:
143ºC

[ Exact Mass ]:
195.12600

[ PSA ]:
52.49000

[ LogP ]:
1.81450

[ Index of Refraction ]:
1.55

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DO6530000
CHEMICAL NAME :
Benzyl alcohol, p-hydroxy-alpha-isopropylaminomethyl-
CAS REGISTRY NUMBER :
7376-66-1
BEILSTEIN REFERENCE NO. :
2098796
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C11-H17-N-O2
MOLECULAR WEIGHT :
195.29
WISWESSER LINE NOTATION :
QR DYQ1MY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,341,1952
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
144 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,341,1952 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1800 mg/kg/12W-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,297,1947

Safety Information

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(Benzyloxy)-phenacyl bromide
  • 3-hydroxy-N-[(5-methoxy-2-nitro-4-phenylmethoxy-phenyl)methylideneamino]naphthalene-2-carboxamide
  • 2-(isopropylamino)acetonitrile hydrochloride
  • Phenol

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 4-[1-Hydroxy-2-(isopropylamino)ethyl]phenol
  • ah 3021
  • ()-N-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulphonamide monohydrochloride
  • (S)-4-(1-HYDROXY-2-(ISOPROPYLAMINO)ETHYL)BENZENE-1,2-DIOL (2R,3R)-2,3-DIHYDROXYSUCCINATE
  • (S)-4-(1-HYDROXY-2-(ISOPROPYLAMINO)ETHYL)BENZENE-1,2-DIOL
  • Sotalol
  • N-((3,5-Dimethylisoxazol-4-yl)methyl)thietan-3-amine
  • 1-(Piperidin-3-yl)-1H-imidazole-4-carboxylic acid
  • [3-(2,2,2-Trifluoroethyl)cyclohexyl]methanamine
  • 1-(Isocyanomethyl)-3-methanesulfonylbenzene
  • 1-(Isocyanomethyl)-2-methanesulfonylbenzene
  • Methyl 3-chloro-2,4,6-trimethylbenzoate
  • Ethyl 2-bromo-3-chloro-5-fluorobenzoate
  • 4-Pyridinecarboxylic acid, 3-[[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]methoxy]-
  • 2-(Cyclobutylmethyl)-1,2,3,4-tetrahydroisoquinolin-7-amine
  • 3-Chloro-4-fluoro-5-methylbenzoic acid
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