4-[1-Hydroxy-2-(isopropylamino)ethyl]phenol
Names
[ CAS No. ]:
7376-66-1
[ Name ]:
4-[1-Hydroxy-2-(isopropylamino)ethyl]phenol
[Synonym ]:
para-phenylethynylphenyl isocyanate
Paraproterenol
Chemical & Physical Properties
[ Density]:
1.099 g/cm3
[ Boiling Point ]:
355.9ºC at 760mmHg
[ Molecular Formula ]:
C11H17NO2
[ Molecular Weight ]:
195.25800
[ Flash Point ]:
143ºC
[ Exact Mass ]:
195.12600
[ PSA ]:
52.49000
[ LogP ]:
1.81450
[ Index of Refraction ]:
1.55
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DO6530000
- CHEMICAL NAME :
- Benzyl alcohol, p-hydroxy-alpha-isopropylaminomethyl-
- CAS REGISTRY NUMBER :
- 7376-66-1
- BEILSTEIN REFERENCE NO. :
- 2098796
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C11-H17-N-O2
- MOLECULAR WEIGHT :
- 195.29
- WISWESSER LINE NOTATION :
- QR DYQ1MY1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 370 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,341,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 144 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,341,1952 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1800 mg/kg/12W-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,297,1947
Safety Information
[ HS Code ]:
2922509090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922509090
[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%