trimipramine

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Names

[ CAS No. ]:
739-71-9

[ Name ]:
trimipramine

[Synonym ]:
(+-)-1-cyclohexyl-1-phenyl-3-piperidino-propan-1-ol,hydrochloride
(+-)-1-Cyclohexyl-1-phenyl-3-piperidino-propan-1-ol,Hydrochlorid
tremin
(+/-)-Trihexyphenidyl hydrochloride
EINECS 212-008-3
Trihexy
5-(3-dimethylamino-2-methylpropyl)-10,11-dihydro-5H-dibenz (b,f) azepine acid maleate
triiodothyronine
Trimipramine
paralest
8-Chloro-3-methoxy-11-(1-methyl-4-piperidinyl)-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ol
[3-(10,11-dihydro-dibenzo[b,f]azepin-5-yl)-2-methyl-propyl]-dimethyl-amine
10,11-dihydro-5-(3-dimethylamino-2-methylpropyl)-5H-dibenz(b,f)azepine
peragit
Sedrina
timipramine
cyclodol
trihexylphenidyl HCl
pacitane
Broflex
3,3',5-triiodothyronine
L-3,3',5-triiodothyronine
3,5,3'-triiodothyronine
pipanol

Chemical & Physical Properties

[ Density]:
0.9912 (rough estimate)

[ Boiling Point ]:
426.2°C (rough estimate)

[ Melting Point ]:
45°

[ Molecular Formula ]:
C20H26N2

[ Molecular Weight ]:
294.43400

[ Flash Point ]:
9℃

[ Exact Mass ]:
294.21000

[ PSA ]:
6.48000

[ LogP ]:
4.18600

[ Index of Refraction ]:
1.6450 (estimate)

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HO1225000
CHEMICAL NAME :
5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)-2-methylpropyl)-10,11-dihydro-
CAS REGISTRY NUMBER :
739-71-9
BEILSTEIN REFERENCE NO. :
1321466
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H26-N2
MOLECULAR WEIGHT :
294.48
WISWESSER LINE NOTATION :
T C676 BN&T&J B1Y1&1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 6,171,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 102,753,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
145 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 155,307,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 102,753,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 155,307,1961

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
16-36/37-45

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Trimipramine N-oxide
  • Iminodibenzyl
  • 3-chloro-2-methylpropyl(dimethyl)amine

DownStream

  • Trimipramine N-oxide

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Related Compounds

  • Trimipramine
  • trimipramine-d3
  • Nortrimipramine
  • Nortrimipramine
  • Hydroxytrimipramine
  • Trimipramine N-oxide
  • 1-(2-Chloropropanoyl)piperidin-4-OL
  • N-(3-Aminophenyl)-2-(2,5-dimethylphenoxy)-propanamide
  • 2-Methoxy-1-[3-(trifluoromethyl)phenyl]ethan-1-amine
  • 3-[1-(2-Fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-YL]propanoic acid
  • N2-Cyclohexyl-N2-ethylpyridine-2,5-diamine
  • 3-methyl-2-(1H-pyrrol-1-yl)pentanoic acid
  • Methyl 4-butoxy-3-methoxybenzoate
  • N-(4-aminophenyl)-3-(2,5-dioxoimidazolidin-1-yl)propanamide
  • 4-(Cyclopentyloxy)-2-methylbenzenamine
  • 4-[(Cyclopentyloxy)methyl]benzenemethanamine