Methyl bromide
Suppliers
Names
[ CAS No. ]:
74-83-9
[ Name ]:
Methyl bromide
[Synonym ]:
Pestmaster
Embafume
methyl bromide
Terabol
Methylbromid
Methane,bromo
Bercema
EINECS 200-813-2
MFCD00000166
Chemical & Physical Properties
[ Density]:
3.3 g/mL at 25 °C(lit.)
[ Boiling Point ]:
4 °C(lit.)
[ Melting Point ]:
−94 °C(lit.)
[ Molecular Formula ]:
CH3Br
[ Molecular Weight ]:
94.93850
[ Flash Point ]:
-34 °C
[ Exact Mass ]:
93.94180
[ LogP ]:
1.01110
[ Vapour density ]:
3.3 (20 °C, vs air)
[ Vapour Pressure ]:
1420 mm Hg ( 20 °C)
[ Index of Refraction ]:
1.4432
[ Stability ]:
Stable. Incompatible with oxidizing agents, strong acids. This is an ozone-depleting chemical, and its use is restricted in many countries.
[ Water Solubility ]:
1.522 g/100 mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PA4900000
- CHEMICAL NAME :
- Methane, bromo-
- CAS REGISTRY NUMBER :
- 74-83-9
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 78
- MOLECULAR FORMULA :
- C-H3-Br
- MOLECULAR WEIGHT :
- 94.95
- WISWESSER LINE NOTATION :
- E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 60000 ppm/2H
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 1 gm/m3/2H
- TOXIC EFFECTS :
- Blood - change in clotting factors
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 35 ppm
- TOXIC EFFECTS :
- Behavioral - anorexia (human) Gastrointestinal - nausea or vomiting Skin and Appendages - corrosive (after topical exposure)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 35 gm/m3/40M-I
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, irritative (after systemic exposure)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 214 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 302 ppm/8H
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1540 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 28900 mg/m3/30M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 300 ppm/9H
- TOXIC EFFECTS :
- Behavioral - muscle weakness Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Skin and Appendages - hair
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21840 mg/kg/2Y-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 120 ppm/6H/13W-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 ppm/6H/5D-I
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 160 ppm/6H/6W-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Cardiac - other changes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 ppm/4H/3W-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 ppm/6H/14D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 ppm/6H/13W-I
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 ppm/6H/6W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - other changes Blood - changes in spleen
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 250 mg/m3/8H/26W-I
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 130 mg/m3/8H/26W-I
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 850 mg/m3/8H/26W-I
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3250 mg/kg/13W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - peritonitis Gastrointestinal - tumors
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 155,41,1985 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 3.9 mg/m3 (1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,187,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,187,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,245,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 15 ppm (60 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,23,1973 OSHA PEL (Gen Indu):CL 20 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 20 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 20 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 20 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-AUSTRALIA:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 5 ppm (20 mg/m3) JAN 1993 OEL-BELGIUM:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 15 ppm (60 mg/m3);STEL 25 ppm (97 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (20 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (20 mg/m3);Skin;Carcinogen JAN 1993 OEL-HUNGARY:TWA 10 mg/m3;STEL 20 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 20 ppm (80 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-SWEDEN:TWA 15 ppm (60 mg/m3);STEL 20 ppm (80 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (20 mg/m3);STEL 10 ppm (40 mg/m3);Skin JAN 1993 OEL-THAILAND:TWA 20 ppm (80 mg/m3) JAN 1993 OEL-TURKEY:TWA 20 ppm (80 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (20 mg/m3);STEL 15 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL BROMIDE-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0420 No. of Facilities: 597 (estimated) No. of Industries: 10 No. of Occupations: 14 No. of Employees: 15899 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0420 No. of Facilities: 513 (estimated) No. of Industries: 4 No. of Occupations: 5 No. of Employees: 5603 (estimated) No. of Female Employees: 975 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H302 + H332-H315-H319-H341-H373-H400-H420
[ Supplemental HS ]:
May form explosive peroxides.
[ Precautionary Statements ]:
P210-P273-P281-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic
[ Risk Phrases ]:
R23/25;R36/37/38;R48/20;R50;R59;R68
[ Safety Phrases ]:
S15-S27-S36/39-S38-S45-S59-S61-S36/37-S26-S24-S16-S7
[ RIDADR ]:
UN 1062 2.3
[ WGK Germany ]:
3
[ RTECS ]:
PA4900000
[ Hazard Class ]:
2.3
[ HS Code ]:
2903399020
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2903399020
[ Summary ]:
2903399020 bromomethane。supervision conditions:14abxy。VAT:17.0%。tax rebate rate:0.0%。MFN tarrif:5.5%。general tariff:30.0%
Articles
Sci. Total Environ. 409(17) , 3106-13, (2011)
The fumigation of freight containers to protect transported goods from fungal and pest infestation has increased worldwide in the last five years due to international regulations requiring fumigation ...
Environ. Sci. Technol. 45(6) , 2317-22, (2011)
Emissions of methyl bromide (MeBr) from agricultural fumigation can lead to depletion of the stratospheric ozone layer, and so its use is being phased out. However, as MeBr is still widely used under ...
Anal. Biochem. 491 , 10-7, (2015)
Cytometry is a versatile and powerful method applicable to different fields, particularly pharmacology and biomedical studies. Based on the data obtained, cytometric studies are classified into high-t...