p-Hydroxy-cinnamic acid
Suppliers
Names
[ CAS No. ]:
7400-08-0
[ Name ]:
p-Hydroxy-cinnamic acid
[Synonym ]:
p-Hydroxycinnamic acid
b-[4-Hydroxyphenyl]acrylic Acid
E-4-HydroxycinnamicAcid
2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)-
4-Coumaric acid
4-Hydroxycinnamic acid
p-Hydroxycinnamic acid, trans
2-Propenoic acid, 3- (4-hydroxyphenyl)-
(2E)-3-(4-Hydroxyphenyl)acrylic acid
(E)-4-Hydroxycinnamic acid
EINECS 231-000-0
trans-p-hydroxycinnamic acid
PARA-HYDROXYCINNAMIC ACID
p-coumaric acid
hydroxycinnamic acid
p-Coumaric acid, trans
trans-4-hydroxycinnamic acid
trans-4-coumaric acid
trans-p-Coumaric Acid
(2E)-3-(4-hydroxyphenyl)prop-2-enoic acid
β-[4-hydroxyphenyl]acrylic acid
p-Hydroxy-cinnamic acid
(E)-p-hydroxycinnamic acid
β-(4-Hydroxyphenyl)acrylic acid
MFCD00004399
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
346.1±17.0 °C at 760 mmHg
[ Melting Point ]:
212-214ºC
[ Molecular Formula ]:
C9H8O3
[ Molecular Weight ]:
164.158
[ Flash Point ]:
177.3±17.4 °C
[ Exact Mass ]:
164.047348
[ PSA ]:
57.53000
[ LogP ]:
1.88
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.660
[ Storage condition ]:
-20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GD9094000
- CHEMICAL NAME :
- Cinnamic acid, p-hydroxy-
- CAS REGISTRY NUMBER :
- 7400-08-0
- BEILSTEIN REFERENCE NO. :
- 2207383
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C9-H8-O3
- MOLECULAR WEIGHT :
- 164.17
- WISWESSER LINE NOTATION :
- QV1U1R DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 657 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 104,793,1984 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2800 mg/kg
- SEX/DURATION :
- male 56 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
- REFERENCE :
- CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 23,677,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 35 mg/kg
- SEX/DURATION :
- female 6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,1285,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 50 mg/kg
- SEX/DURATION :
- female 6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion
- REFERENCE :
- CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 20,49,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 9600 mg/kg
- SEX/DURATION :
- female 12 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 195,575,1977
Safety Information
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S22-S26-S36/37/39
[ WGK Germany ]:
2
[ RTECS ]:
GD9095000