S(+)-4-Aminohexenoic acid

Suppliers

Names

[ Name ]:
S(+)-4-Aminohexenoic acid

[Synonym ]:
(S)-4-aminohex-5-enoic acid
(4S)-4-Aminohex-5-enoic acid
(4S)-4-Amino-5-hexenoic acid
S(+)-|A-Vigabatrin
5-Hexenoic acid,4-amino-,(+)
4-amino-5-hexenoic acid
(S)-vigabatrin(R)
S(+)-4-Aminohexenoic acid
(S)-Vigabatrin
(S)-4-Amino-5-hexenoic Acid
5-Hexenoic acid, 4-amino-, (4S)-
(+)-Vigabatrin
S(+)-γ-Vigabatrin
MFCD00274076

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
277.7±28.0 °C at 760 mmHg

[ Melting Point ]:
166 - 167 °C

[ Molecular Formula ]:
C₆H₁₁NO₂

[ Molecular Weight ]:
129.157

[ Flash Point ]:
121.7±24.0 °C

[ Exact Mass ]:
129.078979

[ PSA ]:
63.32000

[ LogP ]:
-0.10

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.483

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Soluble to 100 mM in water

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

methyl (-)-(4S)-4-[bis(tert-butoxycarbonyl)amino]hex-5-enoate
2-Pyrrolidinone, 5-ethenyl-, (5S)-
Carbon
N-Boc-(S)-Vigabatrin methyl ester
(S)-methyl 4-(2,2,2-trichloroacetamido)hex-5-enoate
6-hydroxyhex-4-enoic acid methyl ester

DownStream

Articles

Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes.

Neuropharmacology 25 , 617-625, (1986)

A preferential effect of valproate on gamma-aminobutyric acid (GABA) in the nerve terminal compartment has been proposed. Gamma-vinyl GABA, an irreversible inhibitor of GABA-transaminase (GABA-T) caus...

An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin.

Eur. J. Pharmacol. 62 , 319, (1980)

Unilateral intrastriatal injection of various substances induces a characteristic dyskinetic syndrome in rats. These substances include picrotoxin as well as a series of irreversible GABA-transaminase...

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