Ketorolac

Suppliers

Names

[ Name ]:
Ketorolac

[Synonym ]:
Lixidol
1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-(phenyl-d-carbonyl)-
5-[(H)Phenylcarbonyl]-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Ketorolac
Tm-asyn
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Fluoxetin
MFCD00864281
1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-
Dolac
Toratex
KETOROLAC-D5
5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Acular
Ketoralac
UNII:YZI5105V0L

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
493.2±40.0 °C at 760 mmHg

[ Melting Point ]:
160-161°C

[ Molecular Formula ]:
C₁₅H₁₃NO₃

[ Molecular Weight ]:
255.269

[ Flash Point ]:
252.1±27.3 °C

[ Exact Mass ]:
255.089539

[ PSA ]:
59.30000

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.659

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY7759800

CHEMICAL NAME :: 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)-

CAS REGISTRY NUMBER :: 74103-06-3

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H13-N-O3

MOLECULAR WEIGHT :: 255.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 12,684,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 12,684,1982

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
3249

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-dicarboxylate
5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid
isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate
2-Benzoylpyrrole
2,3-Dibromo-5-benzoylpyrrole
dimethyl[2-(2,3-dibromo-5-benzoylpyrrol-1-yl)ethyl]malonate
sodium 5-(2-(5-benzoyl-2,3-dibromo-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ide
1N1&VR
Isopropyl 1H-pyrrol-2-ylacetate