Ketorolac

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Names

[ CAS No. ]:
74103-06-3

[ Name ]:
Ketorolac

[Synonym ]:
Lixidol
1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-(phenyl-d-carbonyl)-
5-[(H)Phenylcarbonyl]-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Ketorolac
Tm-asyn
5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Fluoxetin
MFCD00864281
1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-
Dolac
Toratex
KETOROLAC-D5
5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Acular
Ketoralac
UNII:YZI5105V0L

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
493.2±40.0 °C at 760 mmHg

[ Melting Point ]:
160-161°C

[ Molecular Formula ]:
C15H13NO3

[ Molecular Weight ]:
255.269

[ Flash Point ]:
252.1±27.3 °C

[ Exact Mass ]:
255.089539

[ PSA ]:
59.30000

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.659

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY7759800
CHEMICAL NAME :
1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)-
CAS REGISTRY NUMBER :
74103-06-3
LAST UPDATED :
199703
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H13-N-O3
MOLECULAR WEIGHT :
255.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 12,684,1982
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 12,684,1982

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
3249

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-dicarboxylate
  • 5-benzoyl-7-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid
  • isopropyl 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate
  • 2-Benzoylpyrrole
  • 2,3-Dibromo-5-benzoylpyrrole
  • dimethyl[2-(2,3-dibromo-5-benzoylpyrrol-1-yl)ethyl]malonate
  • sodium 5-(2-(5-benzoyl-2,3-dibromo-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ide
  • 1N1&VR
  • Isopropyl 1H-pyrrol-2-ylacetate

DownStream

  • methyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate

Related Compounds

  • KETOROLAC
  • Ketorolac
  • Ketorolac
  • Ketorolac D4
  • Ketorolac D5
  • 1-Keto Ketorolac
  • 1-(5-(2-Amino-5-methylthiazol-4-yl)indolin-1-yl)-2-methylpropan-1-one
  • N,N-dimethyl-4,5-dihydro-3H-spiro[benzo[f][1,4]oxazepine-2,1'-cyclohexan]-4'-amine
  • 2-(7'-methyl-5',7-dioxo-4',5'-dihydro-3'H-spiro[azepane-4,2'-benzo[f][1,4]oxazepin]-1-yl)acetic acid
  • 2-(3',5'-difluoro-[1,1'-biphenyl]-4-yl)-N-ethyltetrahydro-2H-pyran-4-amine
  • (5-(2-Aminothiazol-4-yl)indolin-1-yl)(2-fluorophenyl)methanone
  • Methyl 2-(4-((3-chlorobenzyl)oxy)-3-formylphenyl)acetate
  • Tert-butyl 4-((2-chloropyridin-4-yl)methyl)-2-oxopiperidine-1-carboxylate
  • Tert-butyl 4-(1-(6-bromopyridin-2-yl)-2-methoxy-2-oxoethyl)piperidine-1-carboxylate
  • Tert-butyl 4-((allyloxy)methyl)-4-(2-chloropyridin-4-yl)piperidine-1-carboxylate
  • Tert-butyl 4-carbamoyl-4-(6-chloropyrazin-2-yl)piperidine-1-carboxylate
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