2-Ethyl-4-(4-methyl-1-piperazinyl)-7-nitro-10H-thieno(2,3-b)(1,5)benzo diazepine

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Names

[ CAS No. ]:
74162-45-1

[ Name ]:
2-Ethyl-4-(4-methyl-1-piperazinyl)-7-nitro-10H-thieno(2,3-b)(1,5)benzo diazepine

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Boiling Point ]:
533ºC at 760 mmHg

[ Molecular Formula ]:
C18H21N5O2S

[ Molecular Weight ]:
371.45700

[ Flash Point ]:
276.1ºC

[ Exact Mass ]:
371.14200

[ PSA ]:
104.93000

[ LogP ]:
3.57400

[ Index of Refraction ]:
1.727

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ9006720
CHEMICAL NAME :
10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-ethyl-4-(4-methyl-1-piperazinyl)-7-nitro-
CAS REGISTRY NUMBER :
74162-45-1
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H21-N5-O2-S
MOLECULAR WEIGHT :
371.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,878,1980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-ethyl-7-nitro-5,10-dihydro-benzo[b]thieno[2,3-e][1,4]diazepin-4-one
  • methylpiperazine

DownStream

Related Compounds

  • 1-(5-Bromo-2,4-dichlorophenyl)ethanone
  • Methyl 5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate
  • 5-Hydroxy-6-isopropylnicotinaldehyde
  • Methyl 2-amino-2-(3-bromopyridin-2-yl)acetate
  • 2-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyrazine
  • 6-Chloro-3,4-dimethylthieno[2,3-b]pyridine-2-carboxylic acid
  • 2-(3-Fluoro-4-isobutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 2-(1-Bromo-2-oxopropyl)-6-(chloromethyl)benzonitrile
  • Methyl 2-(2S)-2-azetidinyl-5-fluorobenzoate
  • 4-Thiazolecarboxylic acid, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester
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