2-Ethyl-4-(4-methyl-1-piperazinyl)-7-nitro-10H-thieno(2,3-b)(1,5)benzo diazepine

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Names

[ CAS No. ]:
74162-45-1

[ Name ]:
2-Ethyl-4-(4-methyl-1-piperazinyl)-7-nitro-10H-thieno(2,3-b)(1,5)benzo diazepine

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Boiling Point ]:
533ºC at 760 mmHg

[ Molecular Formula ]:
C18H21N5O2S

[ Molecular Weight ]:
371.45700

[ Flash Point ]:
276.1ºC

[ Exact Mass ]:
371.14200

[ PSA ]:
104.93000

[ LogP ]:
3.57400

[ Index of Refraction ]:
1.727

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ9006720
CHEMICAL NAME :
10H-Thieno(2,3-b)(1,5)benzodiazepine, 2-ethyl-4-(4-methyl-1-piperazinyl)-7-nitro-
CAS REGISTRY NUMBER :
74162-45-1
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H21-N5-O2-S
MOLECULAR WEIGHT :
371.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,878,1980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-ethyl-7-nitro-5,10-dihydro-benzo[b]thieno[2,3-e][1,4]diazepin-4-one
  • methylpiperazine

DownStream

Related Compounds

  • 2-methyl-9-(2-methylbutan-2-yl)-5H,6H,7H,8H,9H-imidazo[1,2-a][1,4]diazepine
  • sodium 5-methyl-1-(pyridin-2-yl)-1H-pyrazole-4-sulfinate
  • 2-ethyl-9-(2-methylpropyl)-5H,6H,7H,8H,9H-imidazo[1,2-a][1,4]diazepine
  • 9-(butan-2-yl)-2-ethyl-5H,6H,7H,8H,9H-imidazo[1,2-a][1,4]diazepine
  • (9R)-9-tert-butyl-2-ethyl-5H,6H,7H,8H,9H-imidazo[1,2-a][1,4]diazepine
  • 9-(2,2-difluoroethyl)-2-ethyl-5H,6H,7H,8H,9H-imidazo[1,2-a][1,4]diazepine
  • 3-{1-Oxa-4,9-diazaspiro[5.5]undecan-9-yl}-3-oxopropanenitrile
  • 2-ethyl-9-(2-fluoroethyl)-5H,6H,7H,8H,9H-imidazo[1,2-a][1,4]diazepine
  • (1r,3r)-3-[(2-Methylpiperazin-1-yl)methyl]cyclobutan-1-amine
  • 3-(1-ethyl-1H-pyrazol-4-yl)furan-2-sulfonamide
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