Losmiprofen

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Names

[ CAS No. ]:
74168-08-4

[ Name ]:
Losmiprofen

[Synonym ]:
Losmiprofen

Chemical & Physical Properties

[ Density]:
1.286g/cm3

[ Boiling Point ]:
469.4ºC at 760 mmHg

[ Molecular Formula ]:
C17H15ClO4

[ Molecular Weight ]:
318.75200

[ Flash Point ]:
237.7ºC

[ Exact Mass ]:
318.06600

[ PSA ]:
63.60000

[ LogP ]:
3.73130

[ Index of Refraction ]:
1.586

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UE8758000
CHEMICAL NAME :
Propionic acid, 2-(3-(p-chlorobenzoyl)-o-tolyloxy)-
CAS REGISTRY NUMBER :
74168-08-4
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H15-Cl-O4
MOLECULAR WEIGHT :
318.77
WISWESSER LINE NOTATION :
QVY1&OR B1 CVR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 15,457,1980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ethyl 2-[3-(4-chlorobenzoyl)-2-methylphenoxy]propanoate

DownStream

Related Compounds

  • 2-[1-(Difluoromethyl)-3,5-dimethylpyrazol-4-yl]acetaldehyde
  • Rel-2-((1s,3s)-3-(trifluoromethoxy)cyclobutyl)acetic acid
  • (5S,8R,9S,10S,13S,14S,17S)-2-bromo-17-hydroxy-2,10,13-trimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
  • 2,3,5,6-Tetrabromo-4-pyridinecarbonitrile
  • 4-Amino-5-chloro-2-methylbenzene-1-sulfonamide
  • 2-Methyl-3-[2-(pyrrolidine-1-carbonyl)morpholin-4-yl]quinoxaline
  • 2-methyl-1-[(1-{5-methylpyrazolo[1,5-a]pyrimidin-7-yl}azetidin-3-yl)methyl]-1H-imidazole
  • 4-(6-{4-[(4-Bromophenyl)methyl]piperazin-1-yl}-2-methylpyrimidin-4-yl)morpholine
  • N-ethyl-4-(4-{pyrazolo[1,5-a]pyrazin-4-yl}piperazin-1-yl)pyrimidin-2-amine
  • 4-{1-[(4-Methylphenyl)methyl]piperidine-3-carbonyl}thiomorpholine
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