Doxazosin

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Names

[ CAS No. ]:
74191-85-8

[ Name ]:
Doxazosin

[Synonym ]:
Doxazosine [French]
1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine
Doxazosinum
Normothen
Cardura
Doxazosina
Doxazosine
Cardura-1
Cardura-2
Cardura-4
MFCD00800482
4-amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone

Chemical & Physical Properties

[ Density]:
1.371 g/cm3

[ Boiling Point ]:
718ºC at 760 mmHg

[ Melting Point ]:
289-290°C

[ Molecular Formula ]:
C23H25N5O5

[ Molecular Weight ]:
451.48

[ Flash Point ]:
388ºC

[ PSA ]:
175.02000

[ LogP ]:
2.88670

[ Storage condition ]:
-20℃

Safety Information

[ Hazard Codes ]:
T,Xi

[ Risk Phrases ]:
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R34:Causes burns. R40:Limited evidence of a carcinogenic effect. R43:May cause sensitization by skin contact. R36/37/38:Irritating to eyes, respiratory system and skin . R38:Irritating

[ Safety Phrases ]:
S36/37-S37/39-S26-S36

[ RIDADR ]:
UN 1198 3/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
LP8925000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Chloro-6,7-dimethoxyquinazolin-4-amine
  • 1-(1,4-Benzodioxane-2-carbonyl)piperazine
  • 2-PIPERAZINE-4- AMINO-6,7 DIMETHOXYQUINAZOLINE
  • 1,2-Benzenediol
  • Ethyl 1,4-benzodioxan-2-carboxylate
  • 1,4-Benzodioxan-2-carboxylic acid

DownStream

Related Compounds

  • Doxazosin
  • Doxazosin D8
  • Doxazosin HCl
  • Doxazosin mesylate
  • 6-hydroxydoxazosin
  • 7-Hydroxydoxazosin
  • (2R,3S)-3-(benzyloxy)-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbutanamido]butanoic acid
  • (2S,3R)-3-(benzyloxy)-2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido]acetamido}butanoic acid
  • (2S,3R)-3-(benzyloxy)-2-{[(1RS,2SR)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopentyl]formamido}butanoic acid
  • (2S)-3-[(2R,3S)-3-(benzyloxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-2-hydroxypropanoic acid
  • 1-[3-(benzyloxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]-3,4-dimethylpyrrolidine-3-carboxylic acid
  • 3-{3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-4-methylpentanamido}-2,2-dimethylpropanoic acid
  • 3-{3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-4-methyl-N-(propan-2-yl)pentanamido}propanoic acid
  • 2-[(2-{2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oxan-4-yl]acetamido}ethyl)sulfanyl]acetic acid
  • 2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbut-2-enamido]-6-fluorobenzoic acid
  • 2-[N-(2,2-dimethylpropyl)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbutanamido]acetic acid
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