Limaprost
Suppliers
Names
[ CAS No. ]:
74397-12-9
[ Name ]:
Limaprost
[Synonym ]:
17S,20-Dimethyl-trans-delta2-PGE1
(E)-7-((1R,2R,3R)-3-Hydroxy-2-((E)-(3S,5S)-3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)-2-heptenoic acid
(2E)-7-{(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methylnon-1-en-1-yl]-5-oxocyclopentyl}hept-2-enoic acid (non-preferred name)
Limaprost
(2E)-7-{(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl}-2-heptenoic acid
9-Oxo-11a,15a-dihydroxy-17S,20-dimethylprosta-trans-2,trans-13-dienoic Acid
17S,20-Dimethyl-trans-2,3-didehydro-PGE1
(2E,11a,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic Acid
17S-Methyl-w-homo-trans-D2-PGE1
ONO 1206
OP 1206
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
550.6±50.0 °C at 760 mmHg
[ Melting Point ]:
97-100°
[ Molecular Formula ]:
C22H36O5
[ Molecular Weight ]:
380.518
[ Flash Point ]:
300.9±26.6 °C
[ Exact Mass ]:
380.256287
[ PSA ]:
94.83000
[ LogP ]:
3.15
[ Appearance of Characters ]:
crystalline
[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C
[ Index of Refraction ]:
1.551
[ Storage condition ]:
−20°C
[ Water Solubility ]:
DMF: soluble
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UK8362500
- CHEMICAL NAME :
- Prost-2,13-dien-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11-alpha,13E,15S,17S)-
- CAS REGISTRY NUMBER :
- 74397-12-9
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2041368
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2041368
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300
[ Precautionary Statements ]:
P264-P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
25
[ Safety Phrases ]:
36/37/39-45
[ RIDADR ]:
UN 2811 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
UK8362500
Articles
Anesth. Analg. 80(3) , 515-20, (1995)
Nerve ischemia induces wallerian degeneration and peripheral neuropathy, the nerve constriction injury induces thermal hyperesthesia. Nerve ischemia is one possible mechanism in the development of the...
Cell. Signal. 4(4) , 453-63, (1992)
We examined the involvement of cAMP-dependent protein kinase (A kinase)2 in the inhibition by cilostamide, a specific inhibitor of the low Km cAMP-phosphodiesterase (PDE), on 9,11-epithio-11,12-methan...
Life Sci. 72(6) , 669-76, (2002)
A synthetic analog of prostaglandin E(1), OP-1206 [17S, 20-dimethyl-trans-Delta(2)-prostaglandin E(1)] protects the small intestine from the methotrexate (MTX)-induced damage. The purpose of this stud...