Geclosporin

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Names

[ Name ]:
Geclosporin

[Synonym ]:
Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl)
cyclosporin G
(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
Cyclosporin A,7-L-norvaline
Cyclosporin Impurity 7

Chemical & Physical Properties

[ Density]:
1.013g/cm3

[ Boiling Point ]:
1297.8ºC at 760 mmHg

[ Molecular Formula ]:
C₆₃H₁₁₃N₁₁O₁₂

[ Molecular Weight ]:
1216.64000

[ Flash Point ]:
738.7ºC

[ Exact Mass ]:
1215.86000

[ PSA ]:
278.80000

[ LogP ]:
4.53960

[ Index of Refraction ]:
1.467

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ4130000

CHEMICAL NAME :: Cyclosporin A, 7-L-norvaline-

CAS REGISTRY NUMBER :: 74436-00-3

LAST UPDATED :: 199506

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C63-H113-N11-O12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 420 mg/kg/28D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal - other changes

REFERENCE :: TRPLAU Transplantation. (Williams & Wilkins, Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1963- Volume(issue)/page/year: 57,1231,1994

Related Compounds

3-(2-naphthamido)-N-(2-methoxyphenyl)benzofuran-2-carboxamide
3-([1,1'-biphenyl]-4-ylcarboxamido)-N-(2-methoxyphenyl)benzofuran-2-carboxamide
(Z)-N-(2-methoxyphenyl)-3-(3-phenylacrylamido)benzofuran-2-carboxamide
(Z)-3-(3-(3,4-dimethoxyphenyl)acrylamido)-N-(2-methoxyphenyl)benzofuran-2-carboxamide
3-(2-(4-chlorophenoxy)acetamido)-N-(2-methoxyphenyl)benzofuran-2-carboxamide
3-(2-([1,1'-biphenyl]-4-yl)acetamido)-N-(2-methoxyphenyl)benzofuran-2-carboxamide
2,3-Dichlorophenyl {[5-(7,9-dimethylpyrido[3',2':4,5]thieno[2,3-E][1,2,4]triazolo[1,5-C]pyrimidin-2-YL)-2-furyl]methyl} ether
N-(2-methoxyphenyl)-3-(2-phenylbutanamido)benzofuran-2-carboxamide
N-(2-methoxyphenyl)-3-(3-phenylpropanamido)-1-benzofuran-2-carboxamide
N-(2-methoxyphenyl)-3-(4-phenylbutanamido)benzofuran-2-carboxamide

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