Geclosporin

Suppliers

Names

[ Name ]:
Geclosporin

[Synonym ]:
Cyclo(((2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-norvalyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl)
cyclosporin G
(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Nva-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
Cyclosporin A,7-L-norvaline
Cyclosporin Impurity 7

Chemical & Physical Properties

[ Density]:
1.013g/cm3

[ Boiling Point ]:
1297.8ºC at 760 mmHg

[ Molecular Formula ]:
C₆₃H₁₁₃N₁₁O₁₂

[ Molecular Weight ]:
1216.64000

[ Flash Point ]:
738.7ºC

[ Exact Mass ]:
1215.86000

[ PSA ]:
278.80000

[ LogP ]:
4.53960

[ Index of Refraction ]:
1.467

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ4130000

CHEMICAL NAME :: Cyclosporin A, 7-L-norvaline-

CAS REGISTRY NUMBER :: 74436-00-3

LAST UPDATED :: 199506

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C63-H113-N11-O12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 420 mg/kg/28D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal - other changes

REFERENCE :: TRPLAU Transplantation. (Williams & Wilkins, Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1963- Volume(issue)/page/year: 57,1231,1994

Related Compounds

[2-(3-Methoxy-2-methylphenyl)ethyl](methyl)amine
5-hydroxy-1-methyl-1H-pyrazole-4-carboxamide
N-(1-Cyano-1-cyclopropylethyl)-2-[(2,2,5,5-tetramethyloxolan-3-YL)amino]acetamide
Ethyl 3-(3-hydroxy-2-oxopyridin-1(2h)-yl)propanoate
3a(2),4a(2)-Dihydro-4-hydroxy-2a(2)-phenyl[3,4a(2)-bi-2H-1-benzopyran]-2-one
2-Amino-2-[3-methoxy-4-(trifluoromethyl)phenyl]ethan-1-ol
1-Methyl-5-(2,2,2-trifluoroethoxy)-1H-pyrazole-3-carboxylic acid
Diethyl ((6-chloropyridin-3-yl)methyl)phosphonate
2-(Oxan-2-yl)propan-1-ol
2-(5-Bromo-3-chloro-2-oxo-1,2-dihydropyridin-1-yl)acetic acid

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.