SPIROPLATIN

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Names

[ CAS No. ]:
74790-08-2

[ Name ]:
SPIROPLATIN

[Synonym ]:
Spiroplatin

Chemical & Physical Properties

[ Boiling Point ]:
198.8ºC at 760 mmHg

[ Molecular Formula ]:
C8H18N2O4PtS

[ Molecular Weight ]:
433.38300

[ Flash Point ]:
83.9ºC

[ Exact Mass ]:
433.06400

[ PSA ]:
140.68000

[ LogP ]:
1.99520

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP2283000
CHEMICAL NAME :
Platinum, (1,1-cyclohexanedimethanamine-N,N')(sulfato(2-)-O,O') -, (SP-4-2)-
CAS REGISTRY NUMBER :
74790-08-2
LAST UPDATED :
199601
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C8-H18-N2-O4-Pt-S
MOLECULAR WEIGHT :
433.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
3 mg/kg/9W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - proteinuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - hamster Kidney
DOSE/DURATION :
1500 nmol/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 25,27,1989

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,1-bis(aminomethyl)cyclohexaneaquosulfatoplatinum(II) monohydrate

DownStream

Related Compounds

  • 2-(3-Amino-2,2-difluoropropyl)-4-bromo-6-fluorophenol
  • O-{2-methyl-2-[3-(1H-1,2,3,4-tetrazol-5-yl)phenyl]propyl}hydroxylamine
  • 4-[(3-methylazetidin-3-yl)oxy]-1-phenyl-1H-pyrazole
  • 1-{6,6-Dimethylbicyclo[3.1.1]heptan-2-yl}-2-methylpropan-2-amine
  • 3-Amino-2-({[(tert-butoxy)carbonyl](propan-2-yl)amino}methyl)propanoic acid
  • 4-(Aminomethyl)-4-(4-ethynylphenyl)cyclohexan-1-ol
  • 1-(Cyclopropylmethyl)-4-oxocyclohexane-1-carboxylic acid
  • 1-[5-(Methoxymethyl)furan-2-yl]-2,2-dimethylcyclopropane-1-carboxylic acid
  • 1-Chloro-4,4,4-trifluoro-3-(trifluoromethyl)butan-2-ol
  • O-[2-(3-chloropyridin-4-yl)ethyl]hydroxylamine
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