isoquinazepon

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Names

[ CAS No. ]:
7492-29-7

[ Name ]:
isoquinazepon

[Synonym ]:
5,9,10,14b-Tetrahydro-2-chloro-5-methylisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one
41-123
Clazolam
2-Chloro-5-methyl-5,9,10,14B-tetrahydroisoquino[2,1-D][1,4]benzodiazepin-6(7H)-one
2-chloro-5-methyl-5,9,10,14b-tetrahydro-benzo[5,6][1,4]diazepino[7,1-a]isoquinolin-6-one
d,l-2-Chlor-5-methyl-5,9,10,14b-tetrahydro-isochino<2,1-d><1,4>benzodiazepin-6(7H)-on
2-Chloro-5,9,10,14b-tetrahydro-5-methylisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one

Chemical & Physical Properties

[ Molecular Formula ]:
C18H17ClN2O

[ Molecular Weight ]:
312.79300

[ Exact Mass ]:
312.10300

[ PSA ]:
23.55000

[ LogP ]:
3.26680

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NW6710000
CHEMICAL NAME :
Isoquino(2,1-d)(1,4)benzodiazepin-6(7H)-one, 5,9,10,14b-tetrahydro-2-chloro-5-methyl-
CAS REGISTRY NUMBER :
7492-29-7
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C18-H17-Cl-N2-O
MOLECULAR WEIGHT :
312.82
WISWESSER LINE NOTATION :
T C6 B676 KN MVN&TT&J N1 RG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1730 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,163,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
465 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,163,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,163,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
233 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,777,1968

Related Compounds

  • Methyl (7-oxo-4,5,6,7-tetrahydrobenzothiazol-2-yl)carbamate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • Methyl 5-(4-chlorophenyl)-1-methyl-1H-pyrazole-3-carboxylate
  • tert-Butyl-DL-alanine