H-Leu-OMe.HCl

Suppliers

Names

[ Name ]:
H-Leu-OMe.HCl

[Synonym ]:
Methyl L-leucinate hydrochloride (1:1)
L-Leucine, methyl ester, hydrochloride (1:1)
EINECS 231-375-0
L-Leucine, methyl ester, hydrochloride
MFCD00012494
methyl (2S)-2-amino-4-methylpentanoate,hydrochloride
H-Leu-OMe·HCl
H-Leu-OMe.HCl

Chemical & Physical Properties

[ Density]:
0.955 g/cm3

[ Boiling Point ]:
169.2ºC at 760 mmHg

[ Melting Point ]:
151-153 °C(lit.)

[ Molecular Formula ]:
C₇H₁₆ClNO₂

[ Molecular Weight ]:
181.660

[ Exact Mass ]:
181.086960

[ PSA ]:
52.32000

[ LogP ]:
2.03510

[ Index of Refraction ]:
13 ° (C=2, H2O)

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Methanol
L-leucine
(2S)-methyl 2-(2-azabicyclo[2.2.1]hept-5-en-2-yl)-4-methylpentanoate
methyl (S)-2-methoxycarbonylamino-4-methyl-valerate
methyl L-leucinate
Z-Leu-Ome
2,2-Dimethoxypropane
L-leucyl chloride

DownStream

(4R)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline
Boc-Phe-Leu-OH
L-Leucine,N2-[(phenylmethoxy)carbonyl]-L-asparaginyl-, methyl ester
METHYL 4-METHYL-2-([(4-METHYLPHENYL)SULFONYL]AMINO)PENTANOATE
N-(2-Carboxy-3-phenylpropanoyl)-L-leucine
2H-Pyrrol-2-one,3-acetyl-1,5-dihydro-4-hydroxy-5-(2-methylpropyl)-
L-leucine
Cbz-pro-Leu-Ome
Cyclo(-leu-pro)
Bestatin hydrochloride

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Nat. Chem. Biol. 5 , 45-52, (2009)

Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting tr...

Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor.

Cell Death Dis. 5 , e1409, (2014)

Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancie...

Primary in vitro immunization with multimeric synthetic peptides of HIV-1 envelope glycoproteins: generation of neutralizing human monoclonal antibodies.

J. Immunol. Methods 176(1) , 9-22, (1994)

Peripheral blood lymphocytes from healthy HIV-1 seronegative donors were immunized in vitro with the following synthetic peptides: (i) an octameric poly-L-lysine conjugated peptide of the HIV-1MN V3 l...

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