6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide

Names

[ Name ]:
6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide

[Synonym ]:
6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide
UNII-267WB8R4TI
2-Naphthalenecarboxamide, 6-(6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-
TAK700
CS-0611
Orteronel,(R)
TAK-700 R-form
(R)-(-)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
685.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₇N₃O₂

[ Molecular Weight ]:
307.346

[ Flash Point ]:
368.2±28.7 °C

[ Exact Mass ]:
307.132080

[ PSA ]:
67.15000

[ LogP ]:
-0.13

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.695

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

TAK-700 (Orteronel)
6-Bromo-2-naphthoic acid
6-bromo-N,N-diisopropyl-2-naphthamide
6-Bromo-N-methyl-2-naphthamide
N,N-diisopropyl-6-[1-hydroxy-1-(1-trityl-1H-imidazol-4-yl)methyl]-2-naphthamide
N,N-diisopropyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide
1-(1H-imidazol-4-yl)prop-2-en-1-one
6-bromonaphthalene-2-carbonyl chloride

DownStream

Related Compounds

4-(3-(Pyridin-3-yl)-4H-1,2,4-triazol-4-yl)butanoic acid
2-hydroxy-4-[3-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl]butanoic acid
1-[3-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl]cyclopropane-1-carboxylic acid
3-(3-(Pyridin-3-yl)-4H-1,2,4-triazol-4-yl)propanoic acid
3-[4-(pyrrolidin-3-yl)-4H-1,2,4-triazol-3-yl]pyridine
2-(3-Methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl)propanoic acid
2-Methyl-2-(3-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl)propanoic acid
3-Methyl-2-(3-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl)butanoic acid
4-[3-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl]butanoic acid
2-hydroxy-4-[3-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl]butanoic acid

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