6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide

Names

[ CAS No. ]:
752243-39-3

[ Name ]:
6-[(7R)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide

[Synonym ]:
6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide
UNII-267WB8R4TI
2-Naphthalenecarboxamide, 6-(6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-
TAK700
CS-0611
Orteronel,(R)
TAK-700 R-form
(R)-(-)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
685.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H17N3O2

[ Molecular Weight ]:
307.346

[ Flash Point ]:
368.2±28.7 °C

[ Exact Mass ]:
307.132080

[ PSA ]:
67.15000

[ LogP ]:
-0.13

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.695

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • TAK-700 (Orteronel)
  • 6-Bromo-2-naphthoic acid
  • 6-bromo-N,N-diisopropyl-2-naphthamide
  • 6-Bromo-N-methyl-2-naphthamide
  • N,N-diisopropyl-6-[1-hydroxy-1-(1-trityl-1H-imidazol-4-yl)methyl]-2-naphthamide
  • N,N-diisopropyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide
  • 1-(1H-imidazol-4-yl)prop-2-en-1-one
  • 6-bromonaphthalene-2-carbonyl chloride

DownStream

Related Compounds

  • 4-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]pentanamido}butanoic acid
  • (2S)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-3-methylpentanoic acid
  • 2-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-N-(propan-2-yl)butanamido}acetic acid
  • 2-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]cyclohexane-1-carboxylic acid
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]cyclopentane-1-carboxylic acid
  • 1-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]cyclopentane-1-carboxylic acid
  • 1-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoyl]-2-methylpiperidine-4-carboxylic acid
  • 3-{1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]-N-methylformamido}propanoic acid
  • 3-[N-ethyl-6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]propanoic acid
  • 3-[N-ethyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]propanoic acid
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